Name: rs327
Published: September 21, 2022
License: Open Access

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs327

Current Build 156

Released September 21, 2022

Organism: Homo sapiens
Position: chr8:19962025 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
Alleles: T>G
Variation Type: SNV Single Nucleotide Variation
Frequency: G=0.313487 (82977/264690, TOPMED)
G=0.285126 (74066/259766, ALFA)
G=0.313698 (43939/140068, GnomAD) (+ 23 more)
G=0.31175 (24535/78700, PAGE_STUDY)
G=0.19442 (5494/28258, 14KJPN)
G=0.19696 (3301/16760, 8.3KJPN)
G=0.3014 (1930/6404, 1000G_30x)
G=0.2925 (1465/5008, 1000G)
G=0.2652 (1188/4480, Estonian)
G=0.2823 (1088/3854, ALSPAC)
G=0.2756 (1022/3708, TWINSUK)
G=0.2085 (611/2930, KOREAN)
G=0.3074 (581/1890, HapMap)
G=0.2020 (370/1832, Korea1K)
G=0.2915 (330/1132, Daghestan)
G=0.280 (279/998, GoNL)
G=0.176 (139/788, PRJEB37584)
G=0.265 (166/626, Chileans)
G=0.250 (150/600, NorthernSweden)
G=0.300 (160/534, MGP)
T=0.404 (105/260, SGDP_PRJ)
G=0.347 (75/216, Qatari)
G=0.192 (41/214, Vietnamese)
G=0.28 (11/40, GENOME_DK)
T=0.50 (11/22, Siberian)
G=0.50 (11/22, Siberian)

Clinical Significance: Reported in ClinVar
Gene : Consequence: LPL : Intron Variant
Publications: 4 citations
Genomic View: See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20230706150541

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	264802	T=0.714991	G=0.285009
European	Sub	228548	T=0.717613	G=0.282387
African	Sub	12008	T=0.60210	G=0.39790
African Others	Sub	446	T=0.531	G=0.469
African American	Sub	11562	T=0.60483	G=0.39517
Asian	Sub	3912	T=0.7855	G=0.2145
East Asian	Sub	3148	T=0.7900	G=0.2100
Other Asian	Sub	764	T=0.767	G=0.233
Latin American 1	Sub	1188	T=0.7298	G=0.2702
Latin American 2	Sub	8774	T=0.7546	G=0.2454
South Asian	Sub	376	T=0.769	G=0.231
Other	Sub	9996	T=0.7245	G=0.2755

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study	Population	Group	Sample Size	Ref Allele	Alt Allele
TopMed	Global	Study-wide	264690	T=0.686513	G=0.313487
Allele Frequency Aggregator	Total	Global	259766	T=0.714874	G=0.285126
Allele Frequency Aggregator	European	Sub	225454	T=0.717166	G=0.282834
Allele Frequency Aggregator	African	Sub	10866	T=0.59875	G=0.40125
Allele Frequency Aggregator	Other	Sub	9196	T=0.7238	G=0.2762
Allele Frequency Aggregator	Latin American 2	Sub	8774	T=0.7546	G=0.2454
Allele Frequency Aggregator	Asian	Sub	3912	T=0.7855	G=0.2145
Allele Frequency Aggregator	Latin American 1	Sub	1188	T=0.7298	G=0.2702
Allele Frequency Aggregator	South Asian	Sub	376	T=0.769	G=0.231
gnomAD - Genomes	Global	Study-wide	140068	T=0.686302	G=0.313698
gnomAD - Genomes	European	Sub	75882	T=0.72449	G=0.27551
gnomAD - Genomes	African	Sub	41936	T=0.59896	G=0.40104
gnomAD - Genomes	American	Sub	13650	T=0.73070	G=0.26930
gnomAD - Genomes	Ashkenazi Jewish	Sub	3322	T=0.6180	G=0.3820
gnomAD - Genomes	East Asian	Sub	3126	T=0.7975	G=0.2025
gnomAD - Genomes	Other	Sub	2152	T=0.7040	G=0.2960
The PAGE Study	Global	Study-wide	78700	T=0.68825	G=0.31175
The PAGE Study	AfricanAmerican	Sub	32514	T=0.59704	G=0.40296
The PAGE Study	Mexican	Sub	10810	T=0.75606	G=0.24394
The PAGE Study	Asian	Sub	8318	T=0.8129	G=0.1871
The PAGE Study	PuertoRican	Sub	7918	T=0.7124	G=0.2876
The PAGE Study	NativeHawaiian	Sub	4534	T=0.8249	G=0.1751
The PAGE Study	Cuban	Sub	4230	T=0.6905	G=0.3095
The PAGE Study	Dominican	Sub	3828	T=0.6852	G=0.3148
The PAGE Study	CentralAmerican	Sub	2450	T=0.7404	G=0.2596
The PAGE Study	SouthAmerican	Sub	1982	T=0.7513	G=0.2487
The PAGE Study	NativeAmerican	Sub	1260	T=0.7381	G=0.2619
The PAGE Study	SouthAsian	Sub	856	T=0.771	G=0.229
14KJPN	JAPANESE	Study-wide	28258	T=0.80558	G=0.19442
8.3KJPN	JAPANESE	Study-wide	16760	T=0.80304	G=0.19696
1000Genomes_30x	Global	Study-wide	6404	T=0.6986	G=0.3014
1000Genomes_30x	African	Sub	1786	T=0.5705	G=0.4295
1000Genomes_30x	Europe	Sub	1266	T=0.6912	G=0.3088
1000Genomes_30x	South Asian	Sub	1202	T=0.7953	G=0.2047
1000Genomes_30x	East Asian	Sub	1170	T=0.7624	G=0.2376
1000Genomes_30x	American	Sub	980	T=0.747	G=0.253
1000Genomes	Global	Study-wide	5008	T=0.7075	G=0.2925
1000Genomes	African	Sub	1322	T=0.5787	G=0.4213
1000Genomes	East Asian	Sub	1008	T=0.7649	G=0.2351
1000Genomes	Europe	Sub	1006	T=0.7068	G=0.2932
1000Genomes	South Asian	Sub	978	T=0.793	G=0.207
1000Genomes	American	Sub	694	T=0.749	G=0.251
Genetic variation in the Estonian population	Estonian	Study-wide	4480	T=0.7348	G=0.2652
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	T=0.7177	G=0.2823
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	T=0.7244	G=0.2756
KOREAN population from KRGDB	KOREAN	Study-wide	2930	T=0.7915	G=0.2085
HapMap	Global	Study-wide	1890	T=0.6926	G=0.3074
HapMap	American	Sub	770	T=0.762	G=0.238
HapMap	African	Sub	690	T=0.574	G=0.426
HapMap	Asian	Sub	254	T=0.787	G=0.213
HapMap	Europe	Sub	176	T=0.716	G=0.284
Korean Genome Project	KOREAN	Study-wide	1832	T=0.7980	G=0.2020
Genome-wide autozygosity in Daghestan	Global	Study-wide	1132	T=0.7085	G=0.2915
Genome-wide autozygosity in Daghestan	Daghestan	Sub	624	T=0.694	G=0.306
Genome-wide autozygosity in Daghestan	Near_East	Sub	144	T=0.708	G=0.292
Genome-wide autozygosity in Daghestan	Central Asia	Sub	122	T=0.787	G=0.213
Genome-wide autozygosity in Daghestan	Europe	Sub	108	T=0.694	G=0.306
Genome-wide autozygosity in Daghestan	South Asian	Sub	98	T=0.69	G=0.31
Genome-wide autozygosity in Daghestan	Caucasus	Sub	36	T=0.78	G=0.22
Genome of the Netherlands Release 5	Genome of the Netherlands	Study-wide	998	T=0.720	G=0.280
CNV burdens in cranial meningiomas	Global	Study-wide	788	T=0.824	G=0.176
CNV burdens in cranial meningiomas	CRM	Sub	788	T=0.824	G=0.176
Chileans	Chilean	Study-wide	626	T=0.735	G=0.265
Northern Sweden	ACPOP	Study-wide	600	T=0.750	G=0.250
Medical Genome Project healthy controls from Spanish population	Spanish controls	Study-wide	534	T=0.700	G=0.300
SGDP_PRJ	Global	Study-wide	260	T=0.404	G=0.596
Qatari	Global	Study-wide	216	T=0.653	G=0.347
A Vietnamese Genetic Variation Database	Global	Study-wide	214	T=0.808	G=0.192
The Danish reference pan genome	Danish	Study-wide	40	T=0.72	G=0.28
Siberian	Global	Study-wide	22	T=0.50	G=0.50

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements

Sequence name	Change
GRCh38.p14 chr 8	NC_000008.11:g.19962025T>G
GRCh37.p13 chr 8	NC_000008.10:g.19819536T>G
LPL RefSeqGene (LRG_1298)	NG_008855.2:g.65309T>G

Gene: LPL, lipoprotein lipase (plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
LPL transcript	NM_000237.3:c.1323-90T>G	N/A	Intron Variant

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: G (allele ID: 1155944 )

ClinVar Accession	Disease Names	Clinical Significance
RCV001513267.5	not provided	Benign

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement	T=	G
GRCh38.p14 chr 8	NC_000008.11:g.19962025=	NC_000008.11:g.19962025T>G
GRCh37.p13 chr 8	NC_000008.10:g.19819536=	NC_000008.10:g.19819536T>G
LPL RefSeqGene (LRG_1298)	NG_008855.2:g.65309=	NG_008855.2:g.65309T>G
LPL transcript	NM_000237.2:c.1323-90=	NM_000237.2:c.1323-90T>G
LPL transcript	NM_000237.3:c.1323-90=	NM_000237.3:c.1323-90T>G

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

141 SubSNP, 25 Frequency, 1 ClinVar submissions

No	Submitter	Submission ID	Date (Build)
1	DEBNICK	ss328	Sep 19, 2000 (36)
2	SC_JCM	ss3630505	Sep 28, 2001 (100)
3	YUSUKE	ss4921959	Aug 28, 2002 (108)
4	BCM_SSAHASNP	ss10440260	Jul 11, 2003 (116)
5	WI_SSAHASNP	ss11926998	Jul 11, 2003 (116)
6	SNP500CANCER	ss12675527	Nov 17, 2003 (118)
7	IMCJ-GDT	ss16343024	Feb 27, 2004 (120)
8	SSAHASNP	ss22698412	Apr 05, 2004 (121)
9	PERLEGEN	ss23712788	Sep 20, 2004 (123)
10	ABI	ss44857773	Mar 15, 2006 (126)
11	ILLUMINA	ss65751060	Oct 13, 2006 (127)
12	PERLEGEN	ss69043155	May 16, 2007 (127)
13	ILLUMINA	ss74889454	Dec 06, 2007 (129)
14	AFFY	ss76733527	Dec 06, 2007 (129)
15	HGSV	ss85144002	Dec 16, 2007 (130)
16	BCMHGSC_JDW	ss93851533	Mar 25, 2008 (129)
17	HUMANGENOME_JCVI	ss98056387	Feb 06, 2009 (130)
18	BGI	ss104512529	Dec 01, 2009 (131)
19	ILLUMINA-UK	ss115864247	Feb 14, 2009 (130)
20	KRIBB_YJKIM	ss119336843	Dec 01, 2009 (131)
21	ENSEMBL	ss142679018	Dec 01, 2009 (131)
22	ENSEMBL	ss143320859	Dec 01, 2009 (131)
23	ILLUMINA	ss160617513	Dec 01, 2009 (131)
24	ILLUMINA	ss173579087	Jul 04, 2010 (132)
25	BUSHMAN	ss198888192	Jul 04, 2010 (132)
26	BCM-HGSC-SUB	ss206489923	Jul 04, 2010 (132)
27	1000GENOMES	ss223585669	Jul 14, 2010 (132)
28	1000GENOMES	ss234352503	Jul 15, 2010 (132)
29	1000GENOMES	ss241227318	Jul 15, 2010 (132)
30	ILLUMINA	ss244294488	Jul 04, 2010 (132)
31	BL	ss254171512	May 09, 2011 (134)
32	GMI	ss279724044	May 04, 2012 (137)
33	PJP	ss294234344	May 09, 2011 (134)
34	ILLUMINA	ss410878567	Sep 17, 2011 (135)
35	ILLUMINA	ss480772131	May 04, 2012 (137)
36	ILLUMINA	ss480787965	May 04, 2012 (137)
37	ILLUMINA	ss481684608	Sep 08, 2015 (146)
38	ILLUMINA	ss485180787	May 04, 2012 (137)
39	ILLUMINA	ss537169900	Sep 08, 2015 (146)
40	TISHKOFF	ss560600156	Apr 25, 2013 (138)
41	SSMP	ss655035591	Apr 25, 2013 (138)
42	ILLUMINA	ss779058949	Sep 08, 2015 (146)
43	ILLUMINA	ss783036563	Sep 08, 2015 (146)
44	ILLUMINA	ss783996060	Sep 08, 2015 (146)
45	ILLUMINA	ss832294246	Sep 08, 2015 (146)
46	ILLUMINA	ss834522084	Sep 08, 2015 (146)
47	EVA-GONL	ss985272682	Aug 21, 2014 (142)
48	JMKIDD_LAB	ss1075340056	Aug 21, 2014 (142)
49	1000GENOMES	ss1328915347	Aug 21, 2014 (142)
50	HAMMER_LAB	ss1397520211	Sep 08, 2015 (146)
51	DDI	ss1431441599	Apr 01, 2015 (144)
52	EVA_GENOME_DK	ss1582593787	Apr 01, 2015 (144)
53	EVA_DECODE	ss1594862343	Apr 01, 2015 (144)
54	EVA_UK10K_ALSPAC	ss1620133813	Apr 01, 2015 (144)
55	EVA_UK10K_TWINSUK	ss1663127846	Apr 01, 2015 (144)
56	EVA_MGP	ss1711194716	Apr 01, 2015 (144)
57	EVA_SVP	ss1713021099	Apr 01, 2015 (144)
58	ILLUMINA	ss1752723247	Sep 08, 2015 (146)
59	HAMMER_LAB	ss1805432816	Sep 08, 2015 (146)
60	WEILL_CORNELL_DGM	ss1928562439	Feb 12, 2016 (147)
61	ILLUMINA	ss1946231547	Feb 12, 2016 (147)
62	ILLUMINA	ss1959093912	Feb 12, 2016 (147)
63	GENOMED	ss1970929955	Jul 19, 2016 (147)
64	JJLAB	ss2024980590	Sep 14, 2016 (149)
65	USC_VALOUEV	ss2153202051	Dec 20, 2016 (150)
66	HUMAN_LONGEVITY	ss2301288393	Dec 20, 2016 (150)
67	SYSTEMSBIOZJU	ss2626975173	Nov 08, 2017 (151)
68	ILLUMINA	ss2634720468	Nov 08, 2017 (151)
69	ILLUMINA	ss2635180598	Nov 08, 2017 (151)
70	GRF	ss2708962559	Nov 08, 2017 (151)
71	ILLUMINA	ss2711132107	Nov 08, 2017 (151)
72	GNOMAD	ss2864093395	Nov 08, 2017 (151)
73	AFFY	ss2986076214	Nov 08, 2017 (151)
74	SWEGEN	ss3002804511	Nov 08, 2017 (151)
75	ILLUMINA	ss3022826109	Nov 08, 2017 (151)
76	BIOINF_KMB_FNS_UNIBA	ss3026281129	Nov 08, 2017 (151)
77	CSHL	ss3348082058	Nov 08, 2017 (151)
78	ILLUMINA	ss3625947309	Oct 12, 2018 (152)
79	ILLUMINA	ss3630013664	Oct 12, 2018 (152)
80	ILLUMINA	ss3632621005	Oct 12, 2018 (152)
81	ILLUMINA	ss3633493728	Oct 12, 2018 (152)
82	ILLUMINA	ss3634220174	Oct 12, 2018 (152)
83	ILLUMINA	ss3635162185	Oct 12, 2018 (152)
84	ILLUMINA	ss3635899144	Oct 12, 2018 (152)
85	ILLUMINA	ss3636899261	Oct 12, 2018 (152)
86	ILLUMINA	ss3637652283	Oct 12, 2018 (152)
87	ILLUMINA	ss3638748377	Oct 12, 2018 (152)
88	ILLUMINA	ss3640869475	Oct 12, 2018 (152)
89	ILLUMINA	ss3643680175	Oct 12, 2018 (152)
90	ILLUMINA	ss3644964721	Oct 12, 2018 (152)
91	OMUKHERJEE_ADBS	ss3646373025	Oct 12, 2018 (152)
92	URBANLAB	ss3648868480	Oct 12, 2018 (152)
93	ILLUMINA	ss3653367066	Oct 12, 2018 (152)
94	EGCUT_WGS	ss3670484555	Jul 13, 2019 (153)
95	EVA_DECODE	ss3721555546	Jul 13, 2019 (153)
96	ILLUMINA	ss3726520380	Jul 13, 2019 (153)
97	ACPOP	ss3735467090	Jul 13, 2019 (153)
98	ILLUMINA	ss3744302895	Jul 13, 2019 (153)
99	ILLUMINA	ss3745461968	Jul 13, 2019 (153)
100	EVA	ss3767717821	Jul 13, 2019 (153)
101	PAGE_CC	ss3771428707	Jul 13, 2019 (153)
102	ILLUMINA	ss3772954561	Jul 13, 2019 (153)
103	PACBIO	ss3786087389	Jul 13, 2019 (153)
104	PACBIO	ss3791353794	Jul 13, 2019 (153)
105	PACBIO	ss3796234961	Jul 13, 2019 (153)
106	KHV_HUMAN_GENOMES	ss3810881301	Jul 13, 2019 (153)
107	EVA	ss3825737082	Apr 26, 2020 (154)
108	EVA	ss3831054946	Apr 26, 2020 (154)
109	EVA	ss3839037608	Apr 26, 2020 (154)
110	EVA	ss3844495632	Apr 26, 2020 (154)
111	SGDP_PRJ	ss3869436811	Apr 26, 2020 (154)
112	KRGDB	ss3916862658	Apr 26, 2020 (154)
113	KOGIC	ss3963402277	Apr 26, 2020 (154)
114	FSA-LAB	ss3984393707	Apr 27, 2021 (155)
115	FSA-LAB	ss3984393708	Apr 27, 2021 (155)
116	EVA	ss3984602266	Apr 27, 2021 (155)
117	EVA	ss3986415492	Apr 27, 2021 (155)
118	EVA	ss4017379948	Apr 27, 2021 (155)
119	TOPMED	ss4778094686	Apr 27, 2021 (155)
120	TOMMO_GENOMICS	ss5187654654	Apr 27, 2021 (155)
121	1000G_HIGH_COVERAGE	ss5276330350	Oct 14, 2022 (156)
122	EVA	ss5315316845	Oct 14, 2022 (156)
123	EVA	ss5379642505	Oct 14, 2022 (156)
124	HUGCELL_USP	ss5472980960	Oct 14, 2022 (156)
125	EVA	ss5509275493	Oct 14, 2022 (156)
126	1000G_HIGH_COVERAGE	ss5566254299	Oct 14, 2022 (156)
127	EVA	ss5623943197	Oct 14, 2022 (156)
128	EVA	ss5624176085	Oct 14, 2022 (156)
129	SANFORD_IMAGENETICS	ss5624688000	Oct 14, 2022 (156)
130	SANFORD_IMAGENETICS	ss5644923958	Oct 14, 2022 (156)
131	TOMMO_GENOMICS	ss5729271311	Oct 14, 2022 (156)
132	EVA	ss5799750260	Oct 14, 2022 (156)
133	EVA	ss5800145671	Oct 14, 2022 (156)
134	YY_MCH	ss5809516785	Oct 14, 2022 (156)
135	EVA	ss5830224536	Oct 14, 2022 (156)
136	EVA	ss5848169564	Oct 14, 2022 (156)
137	EVA	ss5848702271	Oct 14, 2022 (156)
138	EVA	ss5856287115	Oct 14, 2022 (156)
139	EVA	ss5888021718	Oct 14, 2022 (156)
140	EVA	ss5974104455	Oct 14, 2022 (156)
141	EVA	ss5981248386	Oct 14, 2022 (156)
142	1000Genomes	NC_000008.10 - 19819536	Oct 12, 2018 (152)
143	1000Genomes_30x	NC_000008.11 - 19962025	Oct 14, 2022 (156)
144	The Avon Longitudinal Study of Parents and Children	NC_000008.10 - 19819536	Oct 12, 2018 (152)
145	Chileans	NC_000008.10 - 19819536	Apr 26, 2020 (154)
146	Genome-wide autozygosity in Daghestan	NC_000008.9 - 19863816	Apr 26, 2020 (154)
147	Genetic variation in the Estonian population	NC_000008.10 - 19819536	Oct 12, 2018 (152)
148	The Danish reference pan genome	NC_000008.10 - 19819536	Apr 26, 2020 (154)
149	gnomAD - Genomes	NC_000008.11 - 19962025	Apr 27, 2021 (155)
150	Genome of the Netherlands Release 5	NC_000008.10 - 19819536	Apr 26, 2020 (154)
151	HapMap	NC_000008.11 - 19962025	Apr 26, 2020 (154)
152	KOREAN population from KRGDB	NC_000008.10 - 19819536	Apr 26, 2020 (154)
153	Korean Genome Project	NC_000008.11 - 19962025	Apr 26, 2020 (154)
154	Medical Genome Project healthy controls from Spanish population	NC_000008.10 - 19819536	Apr 26, 2020 (154)
155	Northern Sweden	NC_000008.10 - 19819536	Jul 13, 2019 (153)
156	The PAGE Study	NC_000008.11 - 19962025	Jul 13, 2019 (153)
157	CNV burdens in cranial meningiomas	NC_000008.10 - 19819536	Apr 27, 2021 (155)
158	Qatari	NC_000008.10 - 19819536	Apr 26, 2020 (154)
159	SGDP_PRJ	NC_000008.10 - 19819536	Apr 26, 2020 (154)
160	Siberian	NC_000008.10 - 19819536	Apr 26, 2020 (154)
161	8.3KJPN	NC_000008.10 - 19819536	Apr 27, 2021 (155)
162	14KJPN	NC_000008.11 - 19962025	Oct 14, 2022 (156)
163	TopMed	NC_000008.11 - 19962025	Apr 27, 2021 (155)
164	UK 10K study - Twins	NC_000008.10 - 19819536	Oct 12, 2018 (152)
165	A Vietnamese Genetic Variation Database	NC_000008.10 - 19819536	Jul 13, 2019 (153)
166	ALFA	NC_000008.11 - 19962025	Apr 27, 2021 (155)
167	ClinVar	RCV001513267.5	Oct 14, 2022 (156)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID	History Updated (Build)
rs3735961	Oct 08, 2002 (108)
rs61201008	May 26, 2008 (130)

Added to this RefSNP Cluster:

Submission IDs	Observation SPDI	Canonical SPDI	Source RSIDs
494105, ss85144002, ss93851533, ss115864247, ss198888192, ss206489923, ss254171512, ss279724044, ss294234344, ss480772131, ss1397520211, ss1594862343, ss1713021099, ss2635180598, ss3643680175	NC_000008.9:19863815:T:G	NC_000008.11:19962024:T:G	(self)
41010098, 22797217, 429643, 16222803, 8758725, 10186995, 24040052, 310476, 8751955, 151702, 10604369, 21453791, 5718405, 45623961, 22797217, 5083503, ss223585669, ss234352503, ss241227318, ss480787965, ss481684608, ss485180787, ss537169900, ss560600156, ss655035591, ss779058949, ss783036563, ss783996060, ss832294246, ss834522084, ss985272682, ss1075340056, ss1328915347, ss1431441599, ss1582593787, ss1620133813, ss1663127846, ss1711194716, ss1752723247, ss1805432816, ss1928562439, ss1946231547, ss1959093912, ss1970929955, ss2024980590, ss2153202051, ss2626975173, ss2634720468, ss2708962559, ss2711132107, ss2864093395, ss2986076214, ss3002804511, ss3022826109, ss3348082058, ss3625947309, ss3630013664, ss3632621005, ss3633493728, ss3634220174, ss3635162185, ss3635899144, ss3636899261, ss3637652283, ss3638748377, ss3640869475, ss3644964721, ss3646373025, ss3653367066, ss3670484555, ss3735467090, ss3744302895, ss3745461968, ss3767717821, ss3772954561, ss3786087389, ss3791353794, ss3796234961, ss3825737082, ss3831054946, ss3839037608, ss3869436811, ss3916862658, ss3984393707, ss3984393708, ss3984602266, ss3986415492, ss4017379948, ss5187654654, ss5315316845, ss5379642505, ss5509275493, ss5623943197, ss5624176085, ss5624688000, ss5644923958, ss5799750260, ss5800145671, ss5830224536, ss5848169564, ss5848702271, ss5974104455, ss5981248386	NC_000008.10:19819535:T:G	NC_000008.11:19962024:T:G	(self)
RCV001513267.5, 53780234, 289196307, 3581009, 19780278, 650176, 63108415, 615472246, 13634898213, ss2301288393, ss3026281129, ss3648868480, ss3721555546, ss3726520380, ss3771428707, ss3810881301, ss3844495632, ss3963402277, ss4778094686, ss5276330350, ss5472980960, ss5566254299, ss5729271311, ss5809516785, ss5856287115, ss5888021718	NC_000008.11:19962024:T:G	NC_000008.11:19962024:T:G	(self)
ss10440260, ss11926998	NT_030737.7:3540759:T:G	NC_000008.11:19962024:T:G	(self)
ss22698412	NT_030737.8:7630456:T:G	NC_000008.11:19962024:T:G	(self)
ss328, ss3630505, ss4921959, ss12675527, ss16343024, ss23712788, ss44857773, ss65751060, ss69043155, ss74889454, ss76733527, ss98056387, ss104512529, ss119336843, ss142679018, ss143320859, ss160617513, ss173579087, ss244294488, ss410878567	NT_167187.1:7677681:T:G	NC_000008.11:19962024:T:G	(self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

4 citations for rs327

PMID	Title	Author	Year	Journal
19148283	Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.	Deo RC et al.	2009	PLoS genetics
20650961	Application of statistical and functional methodologies for the investigation of genetic determinants of coronary heart disease biomarkers: lipoprotein lipase genotype and plasma triglycerides as an exemplar.	Smith AJ et al.	2010	Human molecular genetics
22629316	Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.	Musunuru K et al.	2012	PloS one
23105935	Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional Study.	Pyun JA et al.	2012	Genomics & informatics

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:

Select flank length:

Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

Reference SNP (rs) Report

rs327