SABRe CVD

FRAMINGHAM HEART STUDY CODING MANUAL

Multiplexed Immunoassay Panel 13 (SABRe Project) - Lab Assay

COHORT: Offspring, Generation 3

TIME INTERVAL: Offspring Cohort Exam 7, Generation 3 Cohort Exam 1

DATASET NAME: l_mpimn13_2005_m_0931s

# OBSERVATIONS: 7351

Variables that define a unique record: SHAREID.

This dataset represents one panel in a series of immunoassay panels done on the same group of participants (Offspring cohort Exam 7 and Gen 3 cohort Exam 1). To get a full set of all the immunoassays panels done, combine the following datasets: l_mpimn01_2005_m_####, l_mpimn02_2005_m_####, l_mpimn03_2005_m_####, etc. (where "####" represents a unique dataset serial number and "mpimnN" represents the Nth immunoassay panel).

Upper CV limits were applied separately to each assay and each cohort to remove extreme CV outliers. The immunoassay value and the CV for all records above this upper CV limit were set to missing.

This dataset is a modified version of the original dataset. Some observations were deleted due to consent restrictions. This coding manual is based on the original dataset. Therefore the value ranges, number of observations and/or cohorts found in the modified dataset, may differ from those stated in this manual.

IDTYPE

Variable name: IDTYPE

Description: Framingham Heart Study cohort identifier

Note: IDTYPE and ID taken together form a unique study participant identification number.

Variable name: ID

Description: Framingham Heart Study participant identifier within a cohort

Note: IDTYPE and ID taken together form a unique study participant identification number.

Note: ID deleted - use SHAREID

SHAREID

Variable name: SHAREID

Description: Unique study participant identification number

RUN_DATE

Variable name: RUN_DATE

Description: Assay run date

Units: Number of days since Exam 1

Note: Date includes month, day and year, however, coding manual displays only month and year to preserve confidentiality.

PLATE_ID

Variable name: PLATE_ID

Description: ID number of plate

Note: Character field

ANAX1

Variable name: ANAX1

Description: Annexin A1

Description: (sample type: plasma)

Units: pg/mL

Note: The lower detectable limit for ANAX1 is 9.76E+02 pg/mL and the upper detectable limit is 7.25E+04 pg/mL. ANAX1 values below or above these limits were set to the lower or upper detectable limit respectively. Use ANAX1_I to see what records are below and above these limits.

ANAX1_CV

Variable name: ANAX1_CV

Description: CV for Annexin A1

Units: %

ANAX1_I

Variable name: ANAX1_I

Description: Indicator variable for Annexin A1

GZMB

Variable name: GZMB

Description: Granzyme B

Description: (sample type: plasma)

Units: pg/mL

Note: The lower detectable limit for GZMB is 5.78E+00 pg/mL and the upper detectable limit is 4.54E+03 pg/mL. GZMB values below or above these limits were set to the lower or upper detectable limit respectively. Use GZMB_I to see what records are below and above these limits.

GZMB_CV

Variable name: GZMB_CV

Description: CV for Granzyme B

Units: %

GZMB_I

Variable name: GZMB_I

Description: Indicator variable for Granzyme B

IGF1R

Variable name: IGF1R

Description: Insulin-like growth factor 1 receptor

Description: (sample type: plasma)

Units: pg/mL

Note: The lower detectable limit for IGF1R is 7.86E+02 pg/mL and the upper detectable limit is 5.73E+05 pg/mL. IGF1R values below or above these limits were set to the lower or upper detectable limit respectively. Use IGF1R_I to see what records are below and above these limits.

Note: IGF1R values were set to unknown if IGF1R_CV was greater than or equal to 137.0 for Offspring (IDTYPE= 1) or 116.0 for Gen 3 (IDTYPE = 3)

IGF1R_CV

Variable name: IGF1R_CV

Description: CV for Insulin-like growth factor 1 receptor

Units: %

Note: IGF1R values were set to unknown if IGF1R_CV was greater than or equal to 137.0 for Offspring (IDTYPE= 1) or 116.0 for Gen 3 (IDTYPE = 3)

IGF1R_I

Variable name: IGF1R_I

Description: Indicator variable for Insulin-like growth factor 1 receptor

MMP8

Variable name: MMP8

Description: Matrix metallopeptidase 8

Description: (sample type: plasma)

Units: pg/mL

Note: The lower detectable limit for MMP8 is 6.76E+01pg/mL and the upper detectable limit is 5.37E+04 pg/mL. MMP8 values below or above these limits were set to the lower or upper detectable limit respectively. Use MMP8_I to see what records are below and above these limits.

Note: MMP8 values were set to unknown if MMP8_CV was greater than or equal to 76.9 for Offspring (IDTYPE= 1) or 98.9 for Gen 3 (IDTYPE = 3)

MMP8_CV

Variable name: MMP8_CV

Description: CV for Matrix metallopeptidase 8

Units: %

Note: MMP8 values were set to unknown if MMP8_CV was greater than or equal to 76.9 for Offspring (IDTYPE= 1) or 98.9 for Gen 3 (IDTYPE = 3)

MMP8_I

Variable name: MMP8_I

Description: Indicator variable for Matrix metallopeptidase 8