SABRe CVD

FRAMINGHAM HEART STUDY CODING MANUAL

Multiplexed Immunoassay Panel 17 (SABRe project) - Lab Assay (blood)

COHORT: Offspring, Generation 3

TIME INTERVAL: Offspring Cohort Exam 7, Generation 3 Cohort Exam 1

DATASET NAME: l_mpimn17_2005_m_0977s

# OBSERVATIONS: 7341

Variables that define a unique record: SHAREID.

This dataset represents one panel in a series of immunoassay panels done on the same group of participants (Offspring cohort Exam 7 and Gen 3 cohort Exam 1). To get a full set of all the immunoassays panels done, combine the following datasets: l_mpimn01_2005_m_####, l_mpimn02_2005_m_####, l_mpimn03_2005_m_####, etc. (where "####" represents a unique dataset serial number and "mpimn0n" represents the nth immunoassay panel).

Upper CV limits were applied separately to each assay and each cohort to remove extreme CV outliers. The immunoassay value and the CV for all records above this upper CV limit were set to missing.

This dataset is a modified version of the original dataset. Some observations were deleted due to consent restrictions. This coding manual is based on the original dataset. Therefore the value ranges, number of observations and/or cohorts found in the modified dataset, may differ from those stated in this manual.

IDTYPE

Variable name: IDTYPE

Description: Framingham Heart Study cohort identifier

Note: IDTYPE and ID taken together form a unique study participant identification number.

Variable name: ID

Description: Framingham Heart Study participant identifier within a cohort

Note: IDTYPE and ID taken together form a unique study participant identification number.

Note: ID deleted - use SHAREID

SHAREID

Variable name: SHAREID

Description: Unique study participant identification number

RUN_DATE

Variable name: RUN_DATE

Description: Assay run date

Units: Number of days since Exam 1

Note: Date includes month, day and year, however, coding manual displays only month and year to preserve confidentiality.

PLATE_ID

Variable name: PLATE_ID

Description: ID number of plate

Note: Character field

ENKUR

Variable name: ENKUR

Description: Enkurin

Description: (sample type: plasma)

Units: pg/mL

Note: The lower detectable limit for ENKUR is 3.31E+03 pg/mL and the upper detectable limit is 8.65E+05 pg/mL. ENKUR values below or above these limits were set to the lower or upper detectable limit respectively. Use ENKUR_I to see what records are below and above these limits.

Note: There were no outlier cutoffs for ENKUR.

ENKUR_CV

Variable name: ENKUR_CV

Description: CV for Enkurin

Units: %

Note: There were no outlier cutoffs for ENKUR.

ENKUR_I

Variable name: ENKUR_I

Description: Indicator variable for Enkurin

UCMGP

Variable name: UCMGP

Description: Uncarboxylated matrix gla protein

Description: (sample type: plasma)

Units: pg/mL

Note: The lower detectable limit for UCMGP is 9.11+03 pg/mL and the upper detectable limit is 2.06E+06 pg/mL. UCMGP values below or above these limits were set to the lower or upper detectable limit respectively. Use UCMGP_I to see what records are below and above these limits.

Note: UCMGP values were set to unknown if UCMGP_CV was greater than or equal to 40.3 for Offspring (IDTYPE = 1) or 58.2 for Gen 3 (IDTYPE = 3).

UCMGP_CV

Variable name: UCMGP_CV

Description: CV for Uncarboxylated matrix gla protein

Units: %

Note: UCMGP values were set to unknown if UCMGP_CV was greater than or equal to 40.3 for Offspring (IDTYPE = 1) or 58.2 for Gen 3 (IDTYPE = 3).

UCMGP_I

Variable name: UCMGP_I

Description: Indicator variable for Uncarboxylated matrix gla protein