Coronary Artery Risk Development in Young Adults (CARDIA) Study - Gene Environment Association Studies Initiative (GENEVA)

This sub-study phs000309 GENEVA CARDIA contains genotype and selected phenotype of subjects available from the phs000309 study. Summary level phenotypes for the NHLBI CARDIA Cohort study participants can be viewed at the top-level study page phs000285 CARDIA Cohort. Individual level phenotype data and molecular data for all CARDIA Cohort top-level study and sub-study are available by requesting Authorized Access to the NHLBI CARDIA Cohort phs000285 study.

For the GENEVA CARDIA project, three genotype call sets were generated from a single set of array scans as a consequence of DNA sample quality problems. These call sets are designated "Birdsuite-1", "Birdsuite-2" and "Beaglecall". ("Beaglecall" used both Birdseed and BEAGLECALL calling algorithms.) An analysis-ready genotypic data set is provided in PLINK format for the "Beaglecall" set only, because it performs very well in QC analyses. Only raw CHP and ALLELE_SUMMARY files are provided for the two Birdsuite call sets because they have significant quality issues. Use of the Beaglecall set is highly recommended. Users of the other two call sets should proceed with caution. More details are given in the genotypic QC report.

The CARDIA study, sponsored by the National Heart, Lung and Blood Institute (NHLBI), is a prospective, multi-center investigation of the natural history and etiology of cardiovascular disease in African-Americans and Whites 18-30 years of age at the time of initial examination. The initial examination included 5,115 participants selectively recruited to represent proportionate racial, gender, age, and education groups from 4 communities: Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA. Participants from the Birmingham, Chicago, and Minneapolis centers were recruited from the total community or from selected census tracts. Participants from the Oakland center were randomly recruited from the Kaiser-Permanente health plan membership. From the time of initiation of the study in 1985-1986, five follow-up examinations have been conducted at years 2, 5, 7, 10, 15, and 20. The Year 25 examination is scheduled to begin in 2010.

This study is part of the Gene Environment Association Studies initiative (GENEVA, http://www.genevastudy.org) funded by the trans-NIH Genes, Environment, and Health Initiative (GEI). The overarching goal is to identify novel genetic factors associated with variation in longitudinal blood pressure profiles during the critical transition period from young adulthood to early middle-age; and to characterize their interactions with relevant environmental factors, such as body weight profiles. Genotyping was performed at the Broad Institute of MIT and Harvard, a GENEVA genotyping center. Data cleaning and harmonization were performed at the GEI-funded GENEVA Coordinating Center at the University of Washington.

• Study Weblinks:
  • CARDIA
• Study Design:
  • Prospective Longitudinal Cohort
• Study Type:
  • Longitudinal
• dbGaP estimated ancestry using GRAF-pop
• Total number of consented subjects: 1926
• Subject Sample Telemetry Report (SSTR)

African-Americans and Whites aged 18-30 at the baseline examination

The cohort has been examined at 7 clinic visits, with an 8th visit scheduled.

Baseline Examination: 1985-1986
Exam 2: 1987-1988
Exam 3: 1990-1991
Exam 4: 1992-1993
Exam 5: 1995-1996
Exam 6: 2000-2001
Exam 7: 2005-2006
Exam 8: (ongoing) 2010-2011

• Primary Phenotype: Cardiovascular Diseases
• Hypertension
• Atherosclerosis
• Obesity
• Lipids
• Diabetes Mellitus
• Smoking
• Pulmonary Function Test
• Physical Activities
• Energy Intake
• Diet

• BioProject
• PubMed
• BioSample
• MeSH
• PMC

• Principal Investigators (Field Centers)
  • Cora E. Lewis, MD. University of Alabama at Birmingham, Birmingham, AL, USA.
  • Kiang Liu, PhD. Northwestern University, Chicago, IL, USA.
  • Pamela Schreiner, PhD. University of Minnesota, Minneapolis, MN, USA.
  • Stephen Sidney, MD. Kaiser Permanente, Oakland, CA, USA.
• Principal Investigator (Coordinating Center)
  • O. Dale Williams, PhD. University of Alabama at Birmingham, Birmingham, AL, USA.
• DNA Laboratory
  • Myriam Fornage, PhD. University of Texas Health Sciences Center, Houston, TX, USA.
• Lipid Laboratory
  • Santica Marcovina, PhD. Northwest Lipid Research Laboratories, Seattle, WA, USA.
• Albuminuria and Chemistry Laboratory
  • Myron Gross, PhD. University of Minnesota, Minneapolis, MN, USA.
• Project Officer
  • Cay Loria, PhD. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.