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- Study Description
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- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
In this study, we investigated the role of the gut microbiota on the development of complications in kidney transplant recipients. We collected serial fecal specimens from 168 kidney transplant recipients within the first 3 months after transplantation. We performed 16S rRNA gene sequencing of the V4-V5 hypervariable region and examined whether the relative gut abundance of pathogenic bacteria was associated with future development of complications like bacteriuria and urinary tract infections. In a subset of samples, we performed metagenomic sequencing of stool and urine supernatant specimens to determine strain level analysis.
- Study Design:
- Prospective Longitudinal Cohort
- Study Type:
- Cohort
- Total number of consented subjects: 169
- Subject Sample Telemetry Report (SSTR)
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- Publicly Available Data (Public ftp)
- Study Inclusion/Exclusion Criteria
Inclusion Criteria: Adult subjects who received a kidney transplant.
- Molecular Data
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Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment 16S rRNA Sequencing Illumina MiSeq N/A N/A Whole Genome Sequencing Illumina NextSeq 500 N/A N/A Whole Genome Sequencing Illumina HiSeq 4000 N/A N/A - Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
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- Primary Phenotype: Urinary Tract Infections
- Microbiota
- Kidney Transplantation
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- Study Attribution
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Principal Investigator
- John Lee, MD, MS. Weill Cornell Medicine, New York, NY, USA.
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Funding Source
- K23AI124464. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
- R21AI133331. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
- R37AI051652. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
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Principal Investigator