RecName: Full=Receptor tyrosine-protein kinase erbB-2; AltName: Full=M - Protein

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Protein 3D Structure

HuA21-scFv in complex with the extracellular domain(ECD) of HER2

PDB: 6J71

Source: Homo sapiens

Method: X-ray Diffraction

Resolution: 2.918 Å

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Articles about the ERBB2 gene

HER2 Affects the Biological Behaviours of Bladder Cancer Cells and is Closely Associated with the Progression and Prognosis of Bladder Cancer. [Arch Esp Urol. 2024]
HER2 Affects the Biological Behaviours of Bladder Cancer Cells and is Closely Associated with the Progression and Prognosis of Bladder Cancer.
Li Q, Su X, Qing L, Xu W, Yang Y, You C, Wang J, Dong Z. Arch Esp Urol. 2024 Jan; 77(1):79-91.
HER2-positive is an independent indicator for predicting pathological complete response to neoadjuvant therapy and Ki67-changed after neoadjuvant chemotherapy predicts favorable prognosis in Chinese women with locally advanced breast cancer. [Medicine (Baltimore). 2024]
HER2-positive is an independent indicator for predicting pathological complete response to neoadjuvant therapy and Ki67-changed after neoadjuvant chemotherapy predicts favorable prognosis in Chinese women with locally advanced breast cancer.
Fang Y, Zhang Q, Wu Y, Wu J. Medicine (Baltimore). 2024 Feb 9; 103(6):e37170.
Characterizing the Genomic Landscape of the Micropapillary Subtype of Urothelial Carcinoma of the Bladder Harboring Activating Extracellular Mutations of ERBB2. [Mod Pathol. 2024]
Characterizing the Genomic Landscape of the Micropapillary Subtype of Urothelial Carcinoma of the Bladder Harboring Activating Extracellular Mutations of ERBB2.
Posada JM, Yakirevich E, Kamat AM, Sood A, Jacob JM, Bratslavsky G, Grivas P, Spiess PE, Li R, Necchi A, et al. Mod Pathol. 2024 Mar; 37(3):100424. Epub 2024 Jan 12.

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Reference sequence information

RefSeq genomic sequence
See the genomic reference sequence for the ERBB2 gene (NG_007503.1).
RefSeq protein isoforms
See 32 reference sequence protein isoforms for the ERBB2 gene.

More about the ERBB2 gene

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand bin...
Also Known As: CD340, HER-2, HER-2/neu...

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BioAssay by Target (Summary)
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LinkOut to external resources

P04626 [Domain Mapping of Disease Mut...]
P04626
Domain Mapping of Disease Mutations
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome

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RecName: Full=Receptor tyrosine-protein kinase erbB-2; AltName: Full=Metastatic ...
RecName: Full=Receptor tyrosine-protein kinase erbB-2; AltName: Full=Metastatic lymph node gene 19 protein; Short=MLN 19; AltName: Full=Proto-oncogene Neu; AltName: Full=Proto-oncogene c-ErbB-2; AltName: Full=Tyrosine kinase-type cell surface receptor HER2; AltName: Full=p185erbB2; AltName: CD_antigen=CD340; Flags: Precursor
gi|119533|sp|P04626.1|ERBB2_HUMAN

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RecName: Full=Receptor tyrosine-protein kinase erbB-2; AltName: Full=Metastatic lymph node gene 19 protein; Short=MLN 19; AltName: Full=Proto-oncogene Neu; AltName: Full=Proto-oncogene c-ErbB-2; AltName: Full=Tyrosine kinase-type cell surface receptor HER2; Al...

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