RecName: Full=Ubiquitin carboxyl-terminal hydrolase 8; AltName: Full=D - Protein

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USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes. [J Cell Biol. 2024]
USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes.
Endo A, Fukushima T, Takahashi C, Tsuchiya H, Ohtake F, Ono S, Ly T, Yoshida Y, Tanaka K, Saeki Y, et al. J Cell Biol. 2024 Mar 4; 223(3). Epub 2024 Jan 5.
Polymorphic USP8 allele promotes Parkinson's disease by inducing the accumulation of α-synuclein through deubiquitination. [Cell Mol Life Sci. 2023]
Polymorphic USP8 allele promotes Parkinson's disease by inducing the accumulation of α-synuclein through deubiquitination.
Wu S, Lin T, Xu Y. Cell Mol Life Sci. 2023 Nov 19; 80(12):363. Epub 2023 Nov 19.
Clinical Spectrum of USP8 Pathogenic Variants in Cushing's Disease. [Arch Med Res. 2023]
Clinical Spectrum of USP8 Pathogenic Variants in Cushing's Disease.
Rebollar-Vega RG, Zuarth-Vázquez JM, Hernández-Ramírez LC. Arch Med Res. 2023 Dec; 54(8):102899. Epub 2023 Nov 2.

RefSeq genomic sequence
See the genomic reference sequence for the USP8 gene (NG_047101.2).
RefSeq protein isoforms
See 3 reference sequence protein isoforms for the USP8 gene.

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Dryad Digital Repository [Dryad Digital Repository]
Dryad Digital Repository
P40818 [Domain Mapping of Disease Mut...]
P40818
Domain Mapping of Disease Mutations
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome

RecName: Full=Ubiquitin carboxyl-terminal hydrolase 8; AltName: Full=Deubiquitin...
RecName: Full=Ubiquitin carboxyl-terminal hydrolase 8; AltName: Full=Deubiquitinating enzyme 8; AltName: Full=Ubiquitin isopeptidase Y; Short=hUBPy; AltName: Full=Ubiquitin thioesterase 8; AltName: Full=Ubiquitin-specific-processing protease 8
gi|731046|sp|P40818.1|UBP8_HUMAN

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