Protein Family Models

This entry represents the region found N-terminal to the neuraminidase domain in the pore forming ABC toxins [1]. Paper describing PDB structure 6ogd. [1]. 31028251. Cryo-EM structures of the pore-forming A subunit from the. Yersinia entomophaga ABC toxin.. Piper SJ, Brillault L, Rothnagel R, Croll TI, Box JK, Chassagnon. I, Scherer S, Goldie KN, Jones SA, Schepers F, Hartley-Tassell. L, Ve T, Busby JN, Dalziel JE, Lott JS, Hankamer B, Stahlberg H,. Hurst MRH, Landsberg MJ;. Nat Commun. 2019;10:1952. (from Pfam)

Date:

2024-04-03

This domain is found in the C-terminal region of the Tc toxin TcA, present in Photorhabdus luminescens. Tc Toxin complexes bind to the cell surface, are endocytosed and perforate the host endosomal membrane by forming channels that translocate toxic enzymes into the host. This domain is responsible for binding to toxin TcB. Binding of TcA to TcB/TcC opens the beta-propeller gate [1]. [1]. 24572368. Mechanism of Tc toxin action revealed in molecular detail.. Meusch D, Gatsogiannis C, Efremov RG, Lang AE, Hofnagel O,. Vetter IR, Aktories K, Raunser S;. Nature. 2014;508:61-65. (from Pfam)

Date:

2024-04-03

This is a neuraminidase-like domain, which is structurally homologous to neuraminidases. It can be found in TcA subunit in tripartite Tc toxin complexes of bacterial pathogens. Functional analysis suggest that the neuraminidase-like domain acts as an electrostatic lock that opens at high or low pH values [1]. [1]. 24572368. Mechanism of Tc toxin action revealed in molecular detail.. Meusch D, Gatsogiannis C, Efremov RG, Lang AE, Hofnagel O,. Vetter IR, Aktories K, Raunser S;. Nature. 2014;508:61-65. (from Pfam)

Date:

2024-04-03

Sequences belonging to this family include SpvA (Salmonella plasmid virulence protein A, which is also called VirA, MkfA, or VRP4), the A subunit of various Tc (toxin complex) toxins, and the VRP1 domain of longer toxins.

Date:

2023-12-12

Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs). [1]. 8969305. The helping hand of collagenase-3 (MMP-13): 2.7 A crystal. structure of its C-terminal haemopexin-like domain.. Gomis-Ruth FX, Gohlke U, Betz M, Knauper V, Murphy G, Lopez-Otin. C, Bode W. J Mol Biol 1996;264:556-566. (from Pfam)

Date:

2024-04-03