Protein Family Models for Protein (Select 1894885767) - Protein Family Models

Select item 4049611.

Date:: 2023-12-12

Family Accession:: NF026165.4
Method:: HMM

Select item 3885732.

HhH-GPD superfamily base excision DNA repair protein

This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate [2]. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases such as Swiss:P53397. The methyl-CPG binding protein MBD4 Swiss:Q9Z2D7 also contains a related domain [1] that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family. [1]. 10499592. The thymine glycosylase MBD4 can bind to the product of. deamination at methylated CpG sites.. Hendrich B, Hardeland U, Ng HH, Jiricny J, Bird A;. Nature 1999;401:301-304.. [2]. 10706276. Structural basis for recognition and repair of the endogenous. mutagen 8-oxoguanine in DNA.. Bruner SD, Norman DP, Verdine GL;. Nature 2000;403:859-866. (from Pfam)

GO Terms:

Biological Process:: base-excision repair (GO:0006284)

Date:: 2024-04-03

Family Accession:: NF012933.4
Method:: HMM

Select item 3589753.

new record, indexing in progress

Family Accession:

Select item 3469874.

new record, indexing in progress

Family Accession:

Select item 3332365.

new record, indexing in progress

Family Accession:

Select item 3158566.

new record, indexing in progress

Family Accession:

Select item 562127.

new record, indexing in progress

Family Accession:

Select item 525538.

A/G-specific adenine glycosylase

A/G-specific adenine glycosylase prevents DNA mutations by excising adenine (A) from the oxidatively damaged guanine (7,8-dihydro-8-oxoguanine or 7-oxoG):adenine base pair

GO Terms:

Molecular Function:: metal ion binding (GO:0046872)

Molecular Function:: purine-specific mismatch base pair DNA N-glycosylase activity (GO:0000701)

Biological Process:: base-excision repair (GO:0006284)

Molecular Function:: 4 iron, 4 sulfur cluster binding (GO:0051539)

Date:: 2023-03-02

Family Accession:: 11439777
Method:: Sparcle

Select item 352089.

new record, indexing in progress

Family Accession:

Select item 2513910.

A/G-specific adenine glycosylase

This equivalog HMM identifies mutY members of the PF00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY.

Gene:: mutY

GO Terms:

Molecular Function:: purine-specific mismatch base pair DNA N-glycosylase activity (GO:0000701)

Biological Process:: DNA repair (GO:0006281)

Date:: 2024-02-28

Family Accession:: TIGR01084.1
Method:: HMM

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