Protein Family Models

This is the catalytic domain of class A beta-lactamases [1]. It is closely related to Beta-lactamase, Pfam:PF00144, the serine beta-lactamase-like superfamily, which contains the distantly related Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase. [1]. 19100272. Structure of PBP-A from Thermosynechococcus elongatus, a. penicillin-binding protein closely related to class A. beta-lactamases.. Urbach C, Evrard C, Pudzaitis V, Fastrez J, Soumillion P,. Declercq JP;. J Mol Biol. 2009;386:109-120. (from Pfam)

Date:

2024-04-03

This model finds serine hydrolases of many sorts, including class C beta-lactamases. Despite the name given by Pfam as a short-hand for this HMM, members proteins should be assumed to be something other than a beta-lactamase if RefSeq or PGAP uses this HMM for naming. True beta-lactamases are named by more specific HMMs.

Date:

2023-12-12

Gene:

bla

Date:

2024-03-19

Members of this family are BlaZ, a family of class A beta-lactamases found discovered in Staphylococcus aureus. Members of this family all share greater than 90% sequence identity. Within this tight group, immunotypic variants described as types A through D have been distinguished (see PMID:2783329). The allele called PC1, from Staphylococcus aureus strain PC1, is an example of a class A beta-lactamase BlaZ of type A. MecA systms for methicillin resistance include a blaZ gene. Note that a related beta-lactamase found in mecC-like systems may be referred to as BlaZ, but shares less than 70% identity and is not included in this family.

Gene:

blaZ

Date:

2024-03-19

class A beta-lactamase-related serine hydrolase, similar to beta lactamases which hydrolyze the amide bond of the beta-lactam ring via the formation of an acyl-enzyme covalent complex

Date:

2018-08-21

Gene:

bla

Date:

2022-02-22