Protein Family Models

The POTRA domain (for polypeptide-transport-associated domain) is found towards the N-terminus of ShlB family proteins (Pfam:PF03865). ShlB is important in the secretion and activation of the haemolysin ShlA. It has been postulated that the POTRA domain has a chaperone-like function over ShlA; it may fold back into the C-terminal beta-barrel channel [1]. [1]. 14559180. POTRA: a conserved domain in the FtsQ family and a class of. beta-barrel outer membrane proteins.. Sanchez-Pulido L, Devos D, Genevrois S, Vicente M, Valencia A;. Trends Biochem Sci 2003;28:523-526. (from Pfam)

Date:

2024-04-03

This family represents a group of sequences that are related to ShlB from Serratia marcescens. ShlB is an outer membrane protein pore involved in the Type Vb or Two-partner secretion system where it is functions to secrete and activate the haemolysin ShlA. The activation of ShlA occurs during secretion when ShlB imposes a conformational change in the inactive haemolysin to form the active protein [1]. [1]. 14688146. Activation of Serratia marcescens hemolysin through a. conformational change.. Walker G, Hertle R, Braun V;. Infect Immun 2004;72:611-614.. [2]. 15119822. Type V protein secretion: simplicity gone awry?.. Desvaux M, Parham NJ, Henderson IR;. Curr Issues Mol Biol 2004;6:111-124.. [3]. 11309114. Two-partner secretion in Gram-negative bacteria: a thrifty,. specific pathway for large virulence proteins.. Jacob-Dubuisson F, Locht C, Antoine R;. Mol Microbiol 2001;40:306-313. (from Pfam)

Date:

2024-04-03