Protein Family Models

SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases) [2]. A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction [3]. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure [5]. [1]. 8725238. The Drosophila ash1 gene product, which is localized at specific. sites on polytene chromosomes, contains a SET domain and a PHD. finger.. Tripoulas N, LaJeunesse D, Gildea J, Shearn A;. Genetics 1996;143:913-928.. [2]. 9537414. Association of SET domain and myotubularin-related proteins. modulates growth control.. Cui X, De Vivo I, Slany R, Miyamoto A, Firestein R, Cleary ML;. Nat Genet 1998;18:331-337.. [3]. 9632640. The PR domain of the Rb-binding zinc finger protein RIZ1 is a. protein binding interface and is related to the SET domain. functioning in chromatin-mediated gene expression.. Huang S, Shao G, Liu L;. J Biol Chem 1998;273:15933-15939.. [4]. 12389037. Structure of the SET domain histone lysine methyltransferase. Clr4.. Min J, Zhang X, Cheng X, Grewal SI, Xu RM;. Nat Struct Biol 2002;0:0-0.. [5]. 12575990. Structure of SET domain proteins:. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-04-03