The OapA domain gets its name from the Haemophilus influenzae protein OapA, which is required for the expression of colony opacity, thus opacity- associated protein A [1]. The OapA protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation [1]. The OapA domain has been shown to bind to peptidoglycan in the E. coli protein YtfB [3]. A screen to identify factors that affect cell division in E. coli discovered that overproducing a fragment of YtfB, including its OapA domain, caused cells to grow as long filaments [3]. OapA domains are commonly associated with other domains that are involved in breaking peptidoglycan cross-links [4]. The OapA domain is distantly related to Pfam:PF01476. [1]. 8559074. Identification and characterization of a cell envelope protein. of Haemophilus influenzae contributing to phase variation in. colony opacity and nasopharyngeal colonization.. Weiser JN, Chong ST, Greenberg D, Fong W;. Mol Microbiol 1995;17:555-564.. [2]. 8830271. Phenotypic switching of Haemophilus influenzae.. Moxon ER, Gewurz BE, Richards JC, Inzana T, Jennings MP, Hood. DW;. Mol Microbiol 1996;19:1149-1150.. [3]. 23565292. Harnessing single cell sorting to identify cell division genes. and regulators in bacteria.. Burke C, Liu M, Britton W, Triccas JA, Thomas T, Smith AL, Allen. S, Salomon R, Harry E;. PLoS One. 2013;8:e60964.. [4]. 29686141. YtfB, an OapA Domain-Containing Protein, Is a New Cell Division. Protein in Escherichia coli.. TRUNCATED at 1650 bytes (from Pfam)
GO Terms:- Molecular Function:
- peptidoglycan binding (GO:0042834)
- Date:
- 2024-04-03