Protein Family Models

DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalysed reaction [1]. The delta subunit is also known as HolA. [1]. 11432857. The delta and delta ' subunits of the DNA polymerase III. holoenzyme are essential for initiation complex formation and. processive elongation.. Song MS, Pham PT, Olson M, Carter JR, Franden MA, Schaaper RM,. McHenry CS;. J Biol Chem 2001;276:35165-35175. (from Pfam)

Date:

2024-04-03

This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00004. Domains I-III are shared between the tau and the gamma subunits, while most of the DnaB-binding Domain IV and all of the alpha-interacting Domain V are unique to tau. [1]. 17355988. The unstructured C-terminus of the tau subunit of Escherichia. coli DNA polymerase III holoenzyme is the site of interaction. with the alpha subunit.. Jergic S, Ozawa K, Williams NK, Su XC, Scott DD, Hamdan SM,. Crowther JA, Otting G, Dixon NE;. Nucleic Acids Res. 2007;35:2813-2824. (from Pfam)

Date:

2024-04-03

AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2]. [1]. 7646486. A 200-amino acid ATPase module in search of a basic function.. Confalonieri F, Duguet M;. Bioessays 1995;17:639-650.. A large extension of the family. [2]. 9927482. AAA+: A class of chaperone-like ATPases associated with the. assembly, operation, and disassembly of protein complexes.. Neuwald AF, Aravind L, Spouge JL, Koonin EV;. Genome Res 1999;9:27-43. (from Pfam)

Date:

2024-04-03

Date:

2020-10-26

Date:

2020-10-26

This model represents the well-conserved first ~ 365 amino acids of the translation of the dnaX gene. The full-length product of the dnaX gene in the model bacterium E. coli is the DNA polymerase III tau subunit. A translational frameshift leads to early termination and a truncated protein subunit gamma, about 1/3 shorter than tau and present in roughly equal amounts. This frameshift mechanism is not necessarily universal for species with DNA polymerase III but appears conserved in the exterme thermophile Thermus thermophilis.

Gene:

dnaX

Date:

2021-04-27

Catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA

Gene:

dnaX

Date:

2021-07-28