Protein Family Models for Protein (Select 500169408) - Protein Family Models

Select item 3948701.

gamma-glutamyl-gamma-aminobutyrate hydrolase family protein

These peptidases have gamma-glutamyl hydrolase activity; that is they catalyse the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to Pfam:PF00117, but contain extensions in four loops and at the C terminus [1]. [1]. 11953431. Three-dimensional structure of human gamma -glutamyl hydrolase.. A class I glatamine amidotransferase adapted for a complex. substate.. Li H, Ryan TJ, Chave KJ, Van Roey P;. J Biol Chem 2002;277:24522-24529. (from Pfam)

GO Terms:

Molecular Function:: hydrolase activity (GO:0016787)

Date:: 2024-04-03

Family Accession:: NF019342.4
Method:: HMM

Select item 3901122.

carbamoyl-phosphate synthase domain-containing protein

The carbamoyl-phosphate synthase domain is in the amino terminus of protein. Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines [1]. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesise carbamoyl phosphate. See Pfam:PF00289. The small chain has a GATase domain in the carboxyl terminus. See Pfam:PF00117. [1]. 1972379. Mammalian carbamyl phosphate synthetase (CPS). DNA sequence and. evolution of the CPS domain of the Syrian hamster. multifunctional protein CAD.. Simmer JP, Kelly RE, Rinker AG Jr, Scully JL, Evans DR;. Biol Chem 1990;265:10395-10402. (from Pfam)

Date:: 2024-04-03

Family Accession:: NF013178.4
Method:: HMM

Select item 3882813.

Glutamine amidotransferase class-I

Date:: 2023-12-12

Family Accession:: NF012345.4
Method:: HMM

Select item 3568034.

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Family Accession:

Select item 3475865.

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Family Accession:

Select item 3463816.

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Family Accession:

Select item 3221077.

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Family Accession:

Select item 3162468.

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Family Accession:

Select item 3155239.

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Family Accession:

Select item 14945910.

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Family Accession:

Select item 14925811.

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Family Accession:

Select item 14144312.

glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit

Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways. This HMM represents the whole of the small chain of the glutamine-dependent form (EC 6.3.5.5) of carbamoyl phosphate synthase, CPSase II. The C-terminal domain has glutamine amidotransferase activity. Note that the sequence from the mammalian urea cycle form has lost the active site Cys, resulting in an ammonia-dependent form, CPSase I (EC 6.3.4.16). CPSases of pyrimidine biosynthesis, arginine biosynthesis, and the urea cycle may be encoded by one or by several genes, depending on the species.

Gene:: carA

GO Terms:

Molecular Function:: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity (GO:0004088)

Cellular Component:: carbamoyl-phosphate synthase complex (GO:0005951)

Biological Process:: pyrimidine ribonucleotide biosynthetic process (GO:0009220)

Date:: 2021-04-27

Family Accession:: TIGR01368.1
Method:: HMM

Select item 13553613.

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Family Accession:

Select item 13530314.

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Family Accession:

Select item 6033915.

carbamoyl-phosphate synthase small subunit

small subunit of carbamoyl phosphate synthetase (CPS) which plays a key role in both arginine and pyrimidine biosynthesis

GO Terms:

Molecular Function:: ligase activity (GO:0016874)

Date:: 2023-03-14

Family Accession:: 11486002
Method:: Sparcle

Select item 3764916.

new record, indexing in progress

Family Accession:

Select item 3753817.

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Family Accession:

Select item 3061918.

carbamoyl phosphate synthase small subunit

GO Terms:

Molecular Function:: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity (GO:0004088)

Biological Process:: glutamine metabolic process (GO:0006541)

Date:: 2021-07-29

Family Accession:: NF009475.0
Method:: HMM

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