Protein Family Models

Peptidase_M48 is the largely extracellular catalytic region of CAAX prenyl protease homologues such as Human FACE-1 protease. These are metallopeptidases, with the characteristic HExxH motif giving the two histidine-zinc-ligands and an adjacent glutamate on the next helix being the third. The whole molecule folds to form a deep groove/cleft into which the substrate can fit [1,2]. [1]. 23539602. Structure of the integral membrane protein CAAX protease Ste24p.. Pryor EE Jr, Horanyi PS, Clark KM, Fedoriw N, Connelly SM,. Koszelak-Rosenblum M, Zhu G, Malkowski MG, Wiener MC, Dumont ME;. Science. 2013;339:1600-1604.. [2]. 23539603. The structural basis of ZMPSTE24-dependent laminopathies.. Quigley A, Dong YY, Pike AC, Dong L, Shrestha L, Berridge G,. Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, von Delft F,. Bullock AN, Burgess-Brown NA, Carpenter EP;. Science. 2013;339:1604-1607. (from Pfam)

Date:

2024-04-03

M48 family metallopeptidase, a member of a zinc metalloprotease family, which typically contains an HExxH motif characteristic of zinc metallopeptidases, and proteolytically removes the C-terminal three residues of farnesylated proteins

Date:

2021-07-20