Abstract
The mouse NK1.1 Ag originally defined as NK cell receptor (NKR)-P1C (CD161) mediates NK cell activation. Here, we show that another member of the mouse CD161 family, NKR-P1B, represents a novel NK1.1 Ag. In contrast to NKR-P1C, which functions as an activating receptor, NKR-P1B inhibits NK cell activation. Association of NKR-P1B with Src homology 2-containing protein tyrosine phosphatase-1 provides a molecular mechanism for this inhibition. The existence of these two NK1.1 Ags with opposite functions suggests a potential role for NKR-P1 molecules, such as those of the Ly-49 gene family, in regulating NK cell function.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens / genetics
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Antigens / metabolism*
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Antigens, Ly
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Antigens, Surface / genetics
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Antigens, Surface / metabolism*
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Blood Cells / immunology
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Cytotoxicity, Immunologic*
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Fetal Blood / immunology
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Intracellular Signaling Peptides and Proteins
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Killer Cells, Natural / immunology*
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Lectins, C-Type*
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Mice
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Mice, Inbred C57BL
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Models, Immunological
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Molecular Sequence Data
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Multigene Family
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NK Cell Lectin-Like Receptor Subfamily B
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Phosphorylation
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Protein Binding
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Protein Phosphatase 1
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Protein Tyrosine Phosphatase, Non-Receptor Type 11
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Protein Tyrosine Phosphatase, Non-Receptor Type 6
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Protein Tyrosine Phosphatases / metabolism
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Proteins / genetics
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Proteins / metabolism*
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Receptors, Immunologic / genetics
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Receptors, Immunologic / metabolism*
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SH2 Domain-Containing Protein Tyrosine Phosphatases
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Sequence Homology, Amino Acid
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Species Specificity
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src Homology Domains
Substances
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Antigens
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Antigens, Ly
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Antigens, Surface
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Intracellular Signaling Peptides and Proteins
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Klrb1c protein, mouse
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Lectins, C-Type
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NK Cell Lectin-Like Receptor Subfamily B
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Proteins
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Receptors, Immunologic
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Protein Phosphatase 1
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Protein Tyrosine Phosphatase, Non-Receptor Type 11
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Protein Tyrosine Phosphatase, Non-Receptor Type 6
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Protein Tyrosine Phosphatases
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Ptpn11 protein, mouse
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Ptpn6 protein, mouse
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SH2 Domain-Containing Protein Tyrosine Phosphatases