Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function

J Immunol. 1999 May 15;162(10):5917-23.

Abstract

The mouse NK1.1 Ag originally defined as NK cell receptor (NKR)-P1C (CD161) mediates NK cell activation. Here, we show that another member of the mouse CD161 family, NKR-P1B, represents a novel NK1.1 Ag. In contrast to NKR-P1C, which functions as an activating receptor, NKR-P1B inhibits NK cell activation. Association of NKR-P1B with Src homology 2-containing protein tyrosine phosphatase-1 provides a molecular mechanism for this inhibition. The existence of these two NK1.1 Ags with opposite functions suggests a potential role for NKR-P1 molecules, such as those of the Ly-49 gene family, in regulating NK cell function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens / genetics
  • Antigens / metabolism*
  • Antigens, Ly
  • Antigens, Surface / genetics
  • Antigens, Surface / metabolism*
  • Blood Cells / immunology
  • Cytotoxicity, Immunologic*
  • Fetal Blood / immunology
  • Intracellular Signaling Peptides and Proteins
  • Killer Cells, Natural / immunology*
  • Lectins, C-Type*
  • Mice
  • Mice, Inbred C57BL
  • Models, Immunological
  • Molecular Sequence Data
  • Multigene Family
  • NK Cell Lectin-Like Receptor Subfamily B
  • Phosphorylation
  • Protein Binding
  • Protein Phosphatase 1
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6
  • Protein Tyrosine Phosphatases / metabolism
  • Proteins / genetics
  • Proteins / metabolism*
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / metabolism*
  • SH2 Domain-Containing Protein Tyrosine Phosphatases
  • Sequence Homology, Amino Acid
  • Species Specificity
  • src Homology Domains

Substances

  • Antigens
  • Antigens, Ly
  • Antigens, Surface
  • Intracellular Signaling Peptides and Proteins
  • Klrb1c protein, mouse
  • Lectins, C-Type
  • NK Cell Lectin-Like Receptor Subfamily B
  • Proteins
  • Receptors, Immunologic
  • Protein Phosphatase 1
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6
  • Protein Tyrosine Phosphatases
  • Ptpn11 protein, mouse
  • Ptpn6 protein, mouse
  • SH2 Domain-Containing Protein Tyrosine Phosphatases