Abstract
Three members of the GATA family of transcription factors, GATA-4, -5, and -6, are expressed in the developing heart. One family member, GATA-5, is restricted to the endocardium while the other two, GATA-4 and -6, are present in the myocardium where they apparently fulfil distinct functions. The mechanisms underlying GATA factor specificity are not fully understood but may involve interaction with other tissue-restricted or ubiquitous co-factors. Thus, combinatorial interaction among GATA factors or between GATA factors and other co-factors may differentially control various stages of cardiogenesis.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Bone Morphogenetic Proteins / genetics
-
Bone Morphogenetic Proteins / physiology
-
Cardiomegaly / genetics
-
Chickens
-
DNA-Binding Proteins / genetics
-
DNA-Binding Proteins / physiology*
-
GATA4 Transcription Factor
-
GATA5 Transcription Factor
-
GATA6 Transcription Factor
-
Gene Expression Regulation, Developmental
-
Heart / embryology*
-
Heart / growth & development
-
Homeobox Protein Nkx-2.5
-
Homeodomain Proteins / genetics
-
Homeodomain Proteins / physiology
-
Humans
-
Mice
-
Myocardium / metabolism
-
Rats
-
Signal Transduction / genetics
-
Transcription Factors / genetics
-
Transcription Factors / physiology*
-
Xenopus
-
Xenopus Proteins*
Substances
-
Bone Morphogenetic Proteins
-
DNA-Binding Proteins
-
GATA-5a protein, Xenopus
-
GATA-5b protein, Xenopus
-
GATA4 Transcription Factor
-
GATA4 protein, Xenopus
-
GATA5 Transcription Factor
-
GATA5 protein, human
-
GATA6 Transcription Factor
-
GATA6 protein, Xenopus
-
GATA6 protein, human
-
Gata5 protein, mouse
-
Gata5 protein, rat
-
Gata6 protein, mouse
-
Homeobox Protein Nkx-2.5
-
Homeodomain Proteins
-
NKX2-5 protein, Xenopus
-
NKX2-5 protein, human
-
Nkx2-5 protein, mouse
-
Transcription Factors
-
Xenopus Proteins