Abstract
Analysis of the sequences of all eight RNA segments of the influenza A/G oose/Guangdong/1/96 (H5N1) virus, isolated from a sick goose during an outbreak in Guangdong province, China, in 1996, revealed that the hemagglutinin (HA) gene of the virus was genetically similar to those of the H5N1 viruses isolated in Hong Kong in 1997. However, the remaining genes showed greater similarity to other avian influenza viruses. Notably, the neuraminidase gene did no have the 19-amino-acid deletion in the stalk region seen in the H5N1 Hong Kong viruses and the NS gene belonged to allele B, while that of the H5N1 Hong Kong viruses belonged to allele A. These data suggest that the H5N1 viruses isolated from the Hong Kong outbreaks derived their HA genes from a virus similar to the A/Goose/Guangdong/1/96 virus or shared a progenitor with this goose pathogen.
MeSH terms
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Animals
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Chickens / virology
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DNA, Viral / chemistry
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DNA, Viral / genetics
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Disease Outbreaks
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Geese / virology*
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Genes, Viral
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Hemagglutinin Glycoproteins, Influenza Virus / genetics*
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Hong Kong / epidemiology
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Humans
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Influenza A Virus, H5N1 Subtype*
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Influenza A virus / classification
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Influenza A virus / genetics*
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Influenza A virus / isolation & purification
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Influenza in Birds / epidemiology
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Influenza in Birds / virology
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Influenza, Human / epidemiology
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Influenza, Human / virology*
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Molecular Sequence Data
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Neuraminidase / genetics
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Phylogeny
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Sequence Analysis, DNA
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Viral Nonstructural Proteins / genetics
Substances
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DNA, Viral
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Hemagglutinin Glycoproteins, Influenza Virus
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Viral Nonstructural Proteins
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Neuraminidase
Associated data
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GENBANK/AF144300
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GENBANK/AF144301
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GENBANK/AF144302
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GENBANK/AF144303
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GENBANK/AF144304
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GENBANK/AF144305
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GENBANK/AF144306
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GENBANK/AF144307