Alternative processing of the human and mouse raly genes(1)

Biochim Biophys Acta. 1999 Oct 6;1447(1):107-12. doi: 10.1016/s0167-4781(99)00126-8.

Abstract

A human homolog(RALY) of the mouse Raly gene was isolated and sequenced, and shown to encode a novel protein isoform containing a 16 amino acid in-frame insert in the variable region of the protein. Analysis of the corresponding region of the mouse Raly gene demonstrated that this novel protein isoform is also present in the mouse. Comparative analysis of RALY cDNA and EST sequences suggests the presence of additional alternatively processed RALY transcripts. As in the mouse, the human RALY gene is widely expressed as a 1.7-kb transcript.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alternative Splicing*
  • Amino Acid Sequence
  • Animals
  • DNA, Complementary / chemistry
  • Expressed Sequence Tags
  • Heterogeneous-Nuclear Ribonucleoprotein Group C*
  • Humans
  • Male
  • Mice
  • Molecular Sequence Data
  • Protein Isoforms / chemistry
  • RNA / chemistry
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Ribonucleoproteins / chemistry
  • Ribonucleoproteins / genetics*
  • Sequence Alignment
  • Testis / metabolism

Substances

  • DNA, Complementary
  • Heterogeneous-Nuclear Ribonucleoprotein Group C
  • Protein Isoforms
  • RALY protein, human
  • RNA-Binding Proteins
  • Raly protein, mouse
  • Ribonucleoproteins
  • RNA

Associated data

  • GENBANK/AF148457
  • GENBANK/AF148458