cDNA cloning of human muskelin and localisation of the muskelin (MKLN1) gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH

Cytogenet Cell Genet. 1999;87(1-2):19-21. doi: 10.1159/000015385.

Abstract

Muskelin is a novel intracellular protein, identified in mouse cells, that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin-1. We report that human muskelin is 98% identical with mouse muskelin at the amino acid level. The human muskelin gene is located at 7q32. The mouse muskelin gene maps syntenically at chromosome 6 B1/B2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Motifs
  • Amino Acid Sequence
  • Animals
  • Cell Adhesion Molecules
  • Chromosomes, Human, Pair 7 / genetics*
  • Cloning, Molecular
  • Conserved Sequence
  • DNA, Complementary / genetics
  • Expressed Sequence Tags
  • Humans
  • In Situ Hybridization, Fluorescence*
  • Intracellular Signaling Peptides and Proteins
  • Mice
  • Molecular Sequence Data
  • Open Reading Frames / genetics
  • Physical Chromosome Mapping*
  • Proteins / chemistry
  • Proteins / genetics*

Substances

  • Cell Adhesion Molecules
  • DNA, Complementary
  • Intracellular Signaling Peptides and Proteins
  • MKLN1 protein, human
  • Mkln1 protein, mouse
  • Proteins

Associated data

  • GENBANK/AF047489