Abstract
The crude extract from the bark and seeds of Khaya grandifoliola was active in vitro against Plasmodium falciparum with an IC50 value of 13.23 microg/ml. The extract was purified to obtain seven limonoids--methylangolensate (1), 6-methylhydroxyangolensate (2), gedunin (3), 7-deacetylkhivorin (5), 1-deacetylkhivorin (6), swietenolide (7), 6-acetylswietenolide (8)--and one flavonoid, catechin (4). Five limonoids (1, 3, 5, 6, 8) were active with IC50 values between 1.25 and 9.63 microg/ml. Catechin was practically devoid of activity. The most active limonoid, gedunin, exhibited an additive effect when combined with chloroquine.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / isolation & purification
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Antimalarials / pharmacology*
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Catechin / isolation & purification
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Catechin / pharmacology*
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Chloroquine / pharmacology
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Drug Therapy, Combination
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Flavonoids / isolation & purification
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Flavonoids / pharmacology*
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In Vitro Techniques
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Inhibitory Concentration 50
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Limonins*
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plasmodium falciparum / drug effects*
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Secosteroids / isolation & purification
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Secosteroids / pharmacology
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Seeds / chemistry
Substances
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Antimalarials
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Flavonoids
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Limonins
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Plant Extracts
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Secosteroids
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gedunin
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Chloroquine
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Catechin