Abstract
[reaction: see text] Novel cholic acid-derived antimicrobial agents that decompose under mildly basic conditions have been prepared. These compounds range in biological properties from potent antibacterial activity to effective permeabilization of the outer membranes of Gram-negative bacteria.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacokinetics
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Anti-Bacterial Agents / pharmacology*
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Cell Membrane Permeability
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Cholic Acids / chemical synthesis*
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Cholic Acids / pharmacokinetics
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Cholic Acids / pharmacology*
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Drug Stability
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Gram-Negative Bacteria / drug effects
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Gram-Negative Bacteria / metabolism
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Gram-Positive Bacteria / drug effects
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Gram-Positive Bacteria / metabolism
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Microbial Sensitivity Tests
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Cholic Acids