Abstract
L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily. In this paper, we identify a new sequence (L6D) that is strikingly similar to L6, IL-TMP, and TM4SF5. Analyses of these four sequences indicate that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 superfamily.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Motifs
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Amino Acid Sequence
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Antigens, CD / chemistry*
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Antigens, CD / genetics
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Antigens, Surface / chemistry*
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Databases, Factual
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Humans
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Membrane Proteins / chemistry*
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Membrane Proteins / genetics
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Membrane Proteins / physiology
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Molecular Sequence Data
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Neoplasm Proteins / chemistry*
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Nerve Tissue Proteins / chemistry*
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Nerve Tissue Proteins / genetics
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Phylogeny
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Platelet Membrane Glycoproteins / chemistry*
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Platelet Membrane Glycoproteins / genetics
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Sequence Alignment
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Sequence Homology, Amino Acid
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Tetraspanin 30
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Tetraspanins
Substances
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Antigens, CD
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Antigens, Surface
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CD63 protein, human
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Membrane Proteins
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Neoplasm Proteins
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Nerve Tissue Proteins
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Platelet Membrane Glycoproteins
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TM4SF5 protein, human
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TSPAN2 protein, human
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Tetraspanin 30
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Tetraspanins
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TM4SF1 protein, human