Abstract
Haemoglobins and myoglobins constitute related protein families that function in oxygen transport and storage in humans and other vertebrates. Here we report the identification of a third globin type in man and mouse. This protein is predominantly expressed in the brain, and therefore we have called it neuroglobin. Mouse neuroglobin is a monomer with a high oxygen affinity (half saturation pressure, P50 approximately 2 torr). Analogous to myoglobin, neuroglobin may increase the availability of oxygen to brain tissue. The human neuroglobin gene (NGB), located on chromosome 14q24, has a unique exon-intron structure. Neuroglobin represents a distinct protein family that diverged early in metazoan evolution, probably before the Protostomia/Deuterostomia split.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Brain / metabolism*
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Chromosome Mapping
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Chromosomes, Human, Pair 14
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Cloning, Molecular
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Exons
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Expressed Sequence Tags
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Gene Expression Profiling
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Globins / biosynthesis*
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Globins / classification
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Globins / genetics
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Globins / isolation & purification
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Humans
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Introns
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Mice
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Mice, Inbred BALB C
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Molecular Sequence Data
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Nerve Tissue Proteins / biosynthesis*
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / isolation & purification
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Neuroglobin
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Oxygen / metabolism
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Recombinant Fusion Proteins
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Sequence Homology, Amino Acid
Substances
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Nerve Tissue Proteins
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Neuroglobin
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Recombinant Fusion Proteins
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Globins
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Oxygen
Associated data
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GENBANK/AA324100
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GENBANK/AF245946
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GENBANK/AJ245944
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GENBANK/AJ245945
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GENBANK/AU036042
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GENBANK/F13069
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GENBANK/R36571