Abstract
Two plant proteins, abrin from the seed of Abrus precatorius and hurin from the seed of Hura crepitans, are potent lymphocyte mitogens. The extent of stimulation of BALB/C AND CBA strain mouse spleens by these factors is significantly greater than that attained with PHA or PWM and requires thymus-derived lymphocytes. Abrin has been purified to electrophoretic homogeneity, physically characterized, and may undergo conversion from a toxic to mitogenic form. Hurin is the best mitogen we have tested.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Abrin* / pharmacology
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Amino Acids / analysis
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Animals
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Drug Stability
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Galactose / analysis
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Glucosamine / analysis
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Lectins* / pharmacology
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Lymphocytes / drug effects
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Lymphocytes / physiology*
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Mannose / analysis
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Mice
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Mice, Inbred BALB C
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Mice, Inbred CBA
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Mitosis / drug effects
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Molecular Weight
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Plant Proteins* / pharmacology
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Spleen / drug effects
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Spleen / physiology
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X-Ray Diffraction
Substances
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Amino Acids
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Lectins
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Plant Proteins
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Abrin
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Glucosamine
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Mannose
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Galactose