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Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel.
Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1182-7. doi: 10.1073/pnas.98.3.1182.
Proc Natl Acad Sci U S A. 2001.
PMID: 11252306
Free PMC article.
The polycystin complex mediates Wnt/Ca(2+) signalling.
Kim S, Nie H, Nesin V, Tran U, Outeda P, Bai CX, Keeling J, Maskey D, Watnick T, Wessely O, Tsiokas L.
Kim S, et al.
Nat Cell Biol. 2016 Jul;18(7):752-764. doi: 10.1038/ncb3363. Epub 2016 May 23.
Nat Cell Biol. 2016.
PMID: 27214281
Free PMC article.
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