Abstract
Many neurodegenerative diseases involve the deposition of insoluble amyloid molecules. In Alzheimer's disease, for example, the amyloid beta-peptide (A beta) is the main component of the characteristic senile plaques. Proteolytic enzymes called secretases are involved in generating A beta, and one of these may have been identified as presenilin--a discovery that paves the way for a more complete understanding of presenilin structure and function.
MeSH terms
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Alzheimer Disease / metabolism
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Amyloid Precursor Protein Secretases
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Amyloid beta-Protein Precursor / genetics
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Amyloid beta-Protein Precursor / physiology
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Animals
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Aspartic Acid Endopeptidases
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Endopeptidases / physiology
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Humans
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Membrane Proteins / chemistry
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Membrane Proteins / metabolism
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Membrane Proteins / physiology*
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Models, Biological
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Mutation
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Neurodegenerative Diseases / metabolism*
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Presenilin-1
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Presenilin-2
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Signal Transduction
Substances
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Amyloid beta-Protein Precursor
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Membrane Proteins
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PSEN1 protein, human
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PSEN2 protein, human
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Presenilin-1
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Presenilin-2
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Amyloid Precursor Protein Secretases
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Endopeptidases
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Aspartic Acid Endopeptidases
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BACE1 protein, human