Intramembrane proteolysis by presenilins

Nat Rev Mol Cell Biol. 2000 Dec;1(3):217-24. doi: 10.1038/35043065.

Abstract

Many neurodegenerative diseases involve the deposition of insoluble amyloid molecules. In Alzheimer's disease, for example, the amyloid beta-peptide (A beta) is the main component of the characteristic senile plaques. Proteolytic enzymes called secretases are involved in generating A beta, and one of these may have been identified as presenilin--a discovery that paves the way for a more complete understanding of presenilin structure and function.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / metabolism
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Protein Precursor / genetics
  • Amyloid beta-Protein Precursor / physiology
  • Animals
  • Aspartic Acid Endopeptidases
  • Endopeptidases / physiology
  • Humans
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism
  • Membrane Proteins / physiology*
  • Models, Biological
  • Mutation
  • Neurodegenerative Diseases / metabolism*
  • Presenilin-1
  • Presenilin-2
  • Signal Transduction

Substances

  • Amyloid beta-Protein Precursor
  • Membrane Proteins
  • PSEN1 protein, human
  • PSEN2 protein, human
  • Presenilin-1
  • Presenilin-2
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • BACE1 protein, human