Diastereomeric diterpenes from Coleus blumei

Chem Pharm Bull (Tokyo). 2001 Jul;49(7):927-9. doi: 10.1248/cpb.49.927.

Abstract

The chloroform extract of the air-dried leaves of Coleus blumei afforded a mixture of diastereomers of a new abietane type diterpene whose structures were elucidated by extensive one and two dimensional (ID, 2D) NMR and mass spectrometry. Acetylation of the mixture afforded a single compound. Antimicrobial tests on the diterpene indicate that it is active against Bacillus subtilis, Pseudomonas aeruginosa and Candida albicans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Bacteria / drug effects
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Microbial Sensitivity Tests
  • Philippines
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry*
  • Stereoisomerism

Substances

  • Diterpenes