Expression patterns of the netrin receptor UNC5H1 among developing motor neurons in the embryonic rat hindbrain

Mech Dev. 2001 Aug;106(1-2):163-6. doi: 10.1016/s0925-4773(01)00415-4.

Abstract

The axon guidance molecule netrin-1 has been implicated in the midline repulsion of developing cranial motor axons. We have examined expression patterns of the netrin receptors UNC5H1 and DCC in embryonic rat hindbrains, in combination with labelling of developing motor neurons. We found that UNC5H1 expression colocalised with a number of cranial motor neuron subpopulations from embryonic day 11 (E11) to E14, while DCC was expressed by motor neurons at E12.

MeSH terms

  • Animals
  • Gene Expression Profiling
  • Gene Expression*
  • Genes, DCC
  • In Situ Hybridization
  • Motor Neurons / metabolism*
  • Netrin Receptors
  • Rats
  • Receptors, Cell Surface / genetics*
  • Rhombencephalon / cytology
  • Rhombencephalon / embryology*
  • Rhombencephalon / metabolism

Substances

  • Netrin Receptors
  • Receptors, Cell Surface