Samioside, a new phenylethanoid glycoside with free-radical scavenging and antimicrobial activities from Phlomis samia

I Kyriakopoulou; P Magiatis; A L Skaltsounis; N Aligiannis; C Harvala

doi:10.1021/np010128+

Samioside, a new phenylethanoid glycoside with free-radical scavenging and antimicrobial activities from Phlomis samia

J Nat Prod. 2001 Aug;64(8):1095-7. doi: 10.1021/np010128+.

Authors

I Kyriakopoulou¹, P Magiatis, A L Skaltsounis, N Aligiannis, C Harvala

Affiliation

¹ Laboratory of Pharmacognosy, University of Athens, Panepistimiopolis, Zografou, GR-15771 Athens, Greece.

PMID: 11520237
DOI: 10.1021/np010128+

Abstract

A new phenylethanoid glycoside, samioside, was isolated from the aerial parts of Phlomis samia and identified as 1-O-3,4-(dihydroxyphenyl)ethyl beta-D-apiofuranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->3)-4-O-caffeoyl-beta-D-glucopyranoside (1). In addition, one known phenylethanoid glycoside and three known flavonoids were identified as acteoside (2), apigenin, chrysoeriol, and ermanin, respectively. The structure of 1 was elucidated on the basis of its spectroscopic data. Samioside (1) demonstrated scavenging properties toward the DPPH radical and antimicrobial activity against Gram-positive and -negative bacteria.

MeSH terms

Anti-Bacterial Agents
Anti-Infective Agents / chemistry
Anti-Infective Agents / isolation & purification*
Anti-Infective Agents / pharmacology
Apigenin
Bepridil / analogs & derivatives*
Bepridil / chemistry
Biphenyl Compounds
Candida / drug effects
Chromatography, Thin Layer
Enterobacter cloacae / drug effects
Escherichia coli / drug effects
Flavones
Flavonoids / chemistry
Flavonoids / isolation & purification
Flavonoids / pharmacology
Free Radical Scavengers / chemistry
Free Radical Scavengers / isolation & purification*
Free Radical Scavengers / pharmacology
Glucosides / chemistry
Glucosides / isolation & purification
Glucosides / pharmacology
Glycosides / chemistry
Glycosides / isolation & purification*
Glycosides / pharmacology
Greece
Klebsiella pneumoniae / drug effects
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Phenols*
Picrates*
Plants, Medicinal / chemistry*
Pseudomonas aeruginosa / drug effects
Spectrophotometry, Infrared
Staphylococcus aureus / drug effects
Staphylococcus epidermidis / drug effects
Stereoisomerism

Substances

Anti-Bacterial Agents
Anti-Infective Agents
Biphenyl Compounds
Flavones
Flavonoids
Free Radical Scavengers
Glucosides
Glycosides
Phenols
Picrates
samioside
ermanin
acteoside
Bepridil
Apigenin
1,1-diphenyl-2-picrylhydrazyl
chrysoeriol