Abstract
By means of subtractive and differential hybridization techniques we have identified a novel murine gene (1A13) the expression of which is developmentally regulated in the mouse brain. Comparison of the nucleotide and predicted protein sequence revealed closest relationship of 1A13 to human CoREST, a transcriptional co-repressor required for regulation of neural-specific gene expression. Thus, we will refer to 1A13 as M-CoREST. As shown by in situ hybridization and Northern blotting, expression of M-CoREST mRNA is abundant in neural tissue at early embryonic stages but declines significantly towards birth, coincident with the progression of CNS maturation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Central Nervous System / embryology*
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Co-Repressor Proteins
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DNA-Binding Proteins*
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Gene Expression Regulation, Developmental
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Humans
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In Situ Hybridization
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Mice
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Molecular Sequence Data
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Nerve Tissue Proteins / genetics*
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Nerve Tissue Proteins / physiology*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Repressor Proteins / genetics*
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Repressor Proteins / physiology*
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Sequence Homology, Amino Acid
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Species Specificity
Substances
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Co-Repressor Proteins
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DNA-Binding Proteins
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Nerve Tissue Proteins
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RCOR1 protein, human
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RNA, Messenger
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Rcor2 protein, mouse
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Repressor Proteins