Pitfalls in the determination of mutant alleles of the thiopurine methyltransferase gene

Leukemia. 2001 Nov;15(11):1792-3. doi: 10.1038/sj.leu.2402285.
No abstract available

Publication types

  • Letter

MeSH terms

  • Alleles
  • Antimetabolites, Antineoplastic / adverse effects
  • Child
  • DNA Restriction Enzymes / chemistry
  • Diagnostic Errors*
  • Gene Frequency
  • Genotype
  • Humans
  • Mercaptopurine / adverse effects
  • Methyltransferases / genetics*
  • Methyltransferases / metabolism
  • Mutation*
  • Polymerase Chain Reaction / methods

Substances

  • Antimetabolites, Antineoplastic
  • Mercaptopurine
  • Methyltransferases
  • thiopurine methyltransferase
  • DNA Restriction Enzymes