BMP signaling pathways in cartilage and bone formation

Crit Rev Eukaryot Gene Expr. 2001;11(1-3):23-45.

Abstract

This review focuses on the molecular aspects of osteogenesis and chondrogenesis as they relate to cellular and developmental levels. We discuss BMP (bone morphogenetic protein)-mediated signaling pathways for the patterning of skeletal elements and mechanisms for the induction of cartilage and bone formation. We emphasize BMP-mediated initiation of chondrogenesis and osteogenesis and consider BMP-dependent signaling cascades in mesenchymal progenitor cells during the development of the axial and appendicular skeleton and during growth plate and joint formation. In particular, we discuss BMP-signaling mediators of the Smad and TAK family and the modulation of these signals by cross-talk and integration with other signaling pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alkaline Phosphatase / biosynthesis
  • Alkaline Phosphatase / genetics
  • Animals
  • Bone Morphogenetic Protein Receptors
  • Bone Morphogenetic Proteins / physiology*
  • Calcitriol / physiology
  • Cartilage / embryology*
  • Cartilage / growth & development
  • Cell Differentiation
  • Chondrocytes / metabolism
  • Embryonic and Fetal Development
  • Extremities / embryology
  • Feedback
  • Gene Expression Regulation, Developmental
  • Growth Plate / growth & development
  • Hedgehog Proteins
  • MAP Kinase Kinase Kinases / physiology
  • MAP Kinase Signaling System
  • Mesoderm / cytology
  • Mice
  • Mice, Inbred C3H
  • Mice, Knockout
  • Models, Biological
  • Multigene Family
  • Osteoblasts / metabolism
  • Osteogenesis / physiology*
  • Proto-Oncogene Proteins / physiology
  • Receptor Tyrosine Kinase-like Orphan Receptors
  • Receptors, Cell Surface / drug effects
  • Receptors, Cell Surface / physiology
  • Receptors, Growth Factor*
  • Signal Transduction / physiology*
  • Somites / physiology
  • Stem Cells / cytology
  • Trans-Activators / physiology
  • Transcription Factors / physiology
  • Wnt Proteins
  • Zebrafish Proteins*

Substances

  • Bone Morphogenetic Proteins
  • Hedgehog Proteins
  • Proto-Oncogene Proteins
  • Receptors, Cell Surface
  • Receptors, Growth Factor
  • Trans-Activators
  • Transcription Factors
  • Wnt Proteins
  • Zebrafish Proteins
  • ROR2 protein, human
  • Receptor Tyrosine Kinase-like Orphan Receptors
  • MAP Kinase Kinase Kinases
  • MAP kinase kinase kinase 7
  • Bone Morphogenetic Protein Receptors
  • Alkaline Phosphatase
  • Calcitriol