Acute coalescent mastoiditis and acoustic sequelae in an infant with severe congenital neutropenia

Int J Pediatr Otorhinolaryngol. 2002 Jan 11;62(1):63-7. doi: 10.1016/s0165-5876(01)00597-3.

Abstract

We report a 2-month-old boy with severe congenital neutropenia (SCN), who developed acute necrotizing otitis media and coalescent mastoiditis due to methicillin-sensitive Staphylococcus aureus. The infection fulminantly progressed within a day to a subtotal perforation of the tympanic membrane, destructive bony changes of ossicles, lateral subperiosteal abscess, and suppurative labyrinthitis. Despite the combined treatment with intravenous antibiotics and granulocyte colony-stimulating factor, the infection resulted in mixed hearing impairment. Much attention should be given to prompt diagnosis of otomastoiditis in SCN, a rare congenital disorder, since resultant acoustic sequelae may affect subsequent speech development and intellectual ability.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Anti-Bacterial Agents
  • Audiometry
  • Drug Therapy, Combination / administration & dosage
  • Follow-Up Studies
  • Granulocyte Colony-Stimulating Factor / administration & dosage
  • Hearing Disorders / diagnosis
  • Hearing Disorders / etiology*
  • Humans
  • Infant
  • Male
  • Mastoiditis / complications
  • Mastoiditis / diagnosis*
  • Mastoiditis / drug therapy
  • Neutropenia / complications
  • Neutropenia / congenital*
  • Neutropenia / drug therapy
  • Otitis Media with Effusion / complications
  • Otitis Media with Effusion / drug therapy
  • Otitis Media with Effusion / microbiology*
  • Risk Assessment
  • Severity of Illness Index
  • Staphylococcal Infections / complications
  • Staphylococcal Infections / diagnosis*
  • Staphylococcal Infections / drug therapy

Substances

  • Anti-Bacterial Agents
  • Granulocyte Colony-Stimulating Factor