Abstract
The methanol extract of Saussurea medusa Maxim afforded two lignans: 2alpha-guaicyl-4-oxo-6alpha-catechyl-3,7-dioxabicyclo [3.3.0]octane and 1alpha-hydroxy-2alpha,4alpha-guaicyl-3,7-dioxabicyclo[3.3.0]octane; two chlorophyll derivatives: 13-epi-phaeophorbide-a and 13-epi-phaeophorbide-a methyl ester; one megastigmane derivative: 3beta-hydroxy-5alpha,6alpha-epoxy-7-megastigmen-9-one, along with 19 known compounds. Their structures were established on the basis of spectroscopic studies.
MeSH terms
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Bridged Bicyclo Compounds, Heterocyclic / isolation & purification
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
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Catechols / isolation & purification
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Catechols / pharmacology*
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Cytokines / antagonists & inhibitors*
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Cytokines / biosynthesis
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Guaiacol / analogs & derivatives
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Guaiacol / isolation & purification
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Guaiacol / pharmacology*
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Immunosuppressive Agents / isolation & purification
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Immunosuppressive Agents / pharmacology*
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Leukocytes, Mononuclear / drug effects
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Leukocytes, Mononuclear / metabolism
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Lignans / isolation & purification
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Lignans / pharmacology
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Saussurea / chemistry*
Substances
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1-hydroxy-2,5-diguaicyl-3,7-dioxabicyclo(3.3.0)octane
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2-guaicyl-4-oxo-6-catechyl-3,7-dioxabicyclo(3.3.0)octane
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Bridged Bicyclo Compounds, Heterocyclic
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Catechols
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Cytokines
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Immunosuppressive Agents
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Lignans
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Guaiacol