Abstract
Ginsenoside-Rb2 derived from ginseng inhibited invasiveness to the basement membrane of endometrial cancer cell lines Ishikawa. HHUA and HEC-1-A cells. These cells dominantly expressed matrix metalloproteinase (MMP)-2 (gelatinase A) among MMPs by zymography. Ginsenoside-Rb2 suppressed the expression and activity of MMP-2, but did not alter the expression of tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in the cells. Therefore, ginsenoside-Rb2 might inhibit invasiveness to the basement membrane via MMP-2 suppression in some endometrial cancers, and can be used as a medicine for inhibition of secondary spreading of uterine endometrial cancers.
MeSH terms
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Antineoplastic Agents / pharmacology*
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Basement Membrane / drug effects
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Blotting, Western
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Endometrial Neoplasms / drug therapy*
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Endometrial Neoplasms / enzymology
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Endometrial Neoplasms / pathology*
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Female
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Ginsenosides*
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Humans
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Immunoenzyme Techniques
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Matrix Metalloproteinase 2 / metabolism*
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Matrix Metalloproteinase Inhibitors
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Neoplasm Invasiveness
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Saponins / pharmacology*
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Tissue Inhibitor of Metalloproteinase-1 / metabolism*
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Tissue Inhibitor of Metalloproteinase-2 / metabolism*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Ginsenosides
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Matrix Metalloproteinase Inhibitors
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Saponins
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Tissue Inhibitor of Metalloproteinase-1
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ginsenoside Rb2
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Tissue Inhibitor of Metalloproteinase-2
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Matrix Metalloproteinase 2