Agastinol and agastenol, novel lignans from Agastache rugosa and their evaluation in an apoptosis inhibition assay

Choonghwan Lee; Hyuna Kim; Yunghee Kho

doi:10.1021/np010425e

Agastinol and agastenol, novel lignans from Agastache rugosa and their evaluation in an apoptosis inhibition assay

J Nat Prod. 2002 Mar;65(3):414-6. doi: 10.1021/np010425e.

Authors

Choonghwan Lee¹, Hyuna Kim, Yunghee Kho

Affiliation

¹ Korea Research Institute of Bioscience and Biotechnology (KRIBB), P.O. Box 115, Yusong, Taejon 305-600, Korea.

PMID: 11908994
DOI: 10.1021/np010425e

Abstract

Investigation of the whole plant of Agastache rugosa resulted in the isolation of two new lignan compounds. Their structures were elucidated as (8S,7'R,8'S)-4-hydroxybenzoic acid 4-(4-hydroxy-3-methoxybenzyl)-2-(4-hydroxy-3-methoxyphenyl)tetrahydrofuran-3-ylmethyl ester (agastinol, 1) and (7'R,8'S)-4-hydroxybenzoic acid 4-(hydroxy-3-methoxybenzylidene)-2-(4-hydroxy-3-methoxyphenyl)-tetrahydrofuran-3-ylmethyl ester (agastenol, 2). Agastinol and agastenol inhibited etoposide-induced apoptosis in U937 cells with IC50 values of 15.2 and 11.4 microg/mL, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis / drug effects
Caspases / analysis
Etoposide / pharmacology
Humans
Inhibitory Concentration 50
Korea
Lignans / chemistry
Lignans / isolation & purification*
Lignans / pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plants, Medicinal / chemistry*
Pyrrolidines / pharmacology
Spectrophotometry, Ultraviolet
Stereoisomerism
Thiocarbamates / pharmacology
Tumor Cells, Cultured / drug effects
U937 Cells / drug effects

Substances

Lignans
Pyrrolidines
Thiocarbamates
agastenol
agastinol
pyrrolidine dithiocarbamic acid
Etoposide
Caspases