Hypophyseal hemorrhage and panhypopituitarism during Puumala Virus Infection: Magnetic Resonance Imaging and detection of viral antigen in the hypophysis

Timo Hautala; Tarja Sironen; Olli Vapalahti; Eija Pääkkö; Terttu Särkioja; Pasi I Salmela; Antti Vaheri; Alexander Plyusnin; Heikki Kauma

doi:10.1086/340859

Hypophyseal hemorrhage and panhypopituitarism during Puumala Virus Infection: Magnetic Resonance Imaging and detection of viral antigen in the hypophysis

Clin Infect Dis. 2002 Jul 1;35(1):96-101. doi: 10.1086/340859. Epub 2002 Jun 6.

Authors

Timo Hautala¹, Tarja Sironen, Olli Vapalahti, Eija Pääkkö, Terttu Särkioja, Pasi I Salmela, Antti Vaheri, Alexander Plyusnin, Heikki Kauma

Affiliation

¹ Department of Internal Medicine, University of Oulu, Oulu, FIN-90014 Oulu, Finland. thautala@sun3.oulu.fi

PMID: 12060884
DOI: 10.1086/340859

Abstract

We describe 3 cases of nephropathia epidemica (NE) that confirm that Puumala virus infection may cause hypophyseal injury. Autopsy revealed a hemorrhagic hypophysis positive for Puumala virus antigen in both neuroendocrine stromal and vascular endothelial cells in 1 patient, and 2 patients developed hypophyseal hemorrhage (diagnosed with magnetic resonance imaging) during or shortly after acute NE, both of whom developed panhypopituitarism.

Publication types

Case Reports

MeSH terms

Adult
Antigens, Viral / analysis*
Hemorrhage / diagnosis*
Hemorrhage / etiology
Hemorrhage / virology
Hemorrhagic Fever with Renal Syndrome / diagnosis*
Hemorrhagic Fever with Renal Syndrome / physiopathology
Humans
Hypopituitarism / diagnosis*
Hypopituitarism / etiology
Hypopituitarism / virology
Magnetic Resonance Imaging
Male
Middle Aged
Pituitary Diseases / diagnosis
Pituitary Diseases / etiology
Pituitary Diseases / virology
Pituitary Gland / virology*
Puumala virus*

Substances

Antigens, Viral