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SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.
Mol Pharmacol. 2002 Jul;62(1):65-74. doi: 10.1124/mol.62.1.65.
Mol Pharmacol. 2002.
PMID: 12065756
Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab.
Wang SE, Xiang B, Guix M, Olivares MG, Parker J, Chung CH, Pandiella A, Arteaga CL.
Wang SE, et al.
Mol Cell Biol. 2008 Sep;28(18):5605-20. doi: 10.1128/MCB.00787-08. Epub 2008 Jul 14.
Mol Cell Biol. 2008.
PMID: 18625725
Free PMC article.
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