Abstract
Two new diterpene lactones, suregadolides A (1) and B (2), were isolated from a dichloromethane extract of Suregada multiflora bark. These compounds possess a novel skeleton, which contains a cyclopropane ring bridging C-3 and C-4 of the abietane skeleton. The structures were established on the basis of one- and two-dimensional NMR and other spectroscopic studies. Compound 1 showed moderate inhibitory activity in a mutant yeast strain bioassay.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Bangladesh
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Euphorbiaceae / chemistry*
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Microbial Sensitivity Tests
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Organisms, Genetically Modified
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Plant Bark / chemistry
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Plants, Medicinal / chemistry*
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Saccharomyces cerevisiae / drug effects
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Stereoisomerism
Substances
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Antifungal Agents
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Diterpenes
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Lactones
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suregadolide A
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suregadolide B