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The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs.
Amour A, Knight CG, English WR, Webster A, Slocombe PM, Knäuper V, Docherty AJ, Becherer JD, Blobel CP, Murphy G. Amour A, et al. FEBS Lett. 2002 Jul 31;524(1-3):154-8. doi: 10.1016/s0014-5793(02)03047-8. FEBS Lett. 2002. PMID: 12135759 Free article.