Abstract
The protective potential of antibodies directed against group B streptococcus (GBS) Sip surface protein was determined by using the mouse neonatal infection model. Rabbit Sip-specific antibodies administered passively to pregnant mice protected their pups against a GBS lethal challenge. In addition, active immunization with purified recombinant Sip protein of female CD-1 mice induced the production of specific antibodies that also confer protection to the newborn pups against GBS strains of serotypes Ia/c, Ib, II, III, and V. These data confirm that Sip-specific antibodies can cross the placenta and conferred protective immunity against GBS infections.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Antibodies, Bacterial / administration & dosage
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Antigens, Bacterial / administration & dosage
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Antigens, Bacterial / immunology*
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Disease Models, Animal
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Female
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Immunity, Maternally-Acquired*
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Immunization, Passive
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Mice
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Pregnancy
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Rabbits
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Recombinant Proteins / administration & dosage
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Recombinant Proteins / immunology
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Streptococcal Infections / immunology*
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Streptococcal Infections / prevention & control*
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Streptococcus agalactiae / classification
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Streptococcus agalactiae / immunology*
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Vaccination
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Recombinant Proteins
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SIP protein, Streptococcus group B