Protection from group B streptococcal infection in neonatal mice by maternal immunization with recombinant Sip protein

Infect Immun. 2002 Sep;70(9):4897-901. doi: 10.1128/IAI.70.9.4897-4901.2002.

Abstract

The protective potential of antibodies directed against group B streptococcus (GBS) Sip surface protein was determined by using the mouse neonatal infection model. Rabbit Sip-specific antibodies administered passively to pregnant mice protected their pups against a GBS lethal challenge. In addition, active immunization with purified recombinant Sip protein of female CD-1 mice induced the production of specific antibodies that also confer protection to the newborn pups against GBS strains of serotypes Ia/c, Ib, II, III, and V. These data confirm that Sip-specific antibodies can cross the placenta and conferred protective immunity against GBS infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Antibodies, Bacterial / administration & dosage
  • Antigens, Bacterial / administration & dosage
  • Antigens, Bacterial / immunology*
  • Disease Models, Animal
  • Female
  • Immunity, Maternally-Acquired*
  • Immunization, Passive
  • Mice
  • Pregnancy
  • Rabbits
  • Recombinant Proteins / administration & dosage
  • Recombinant Proteins / immunology
  • Streptococcal Infections / immunology*
  • Streptococcal Infections / prevention & control*
  • Streptococcus agalactiae / classification
  • Streptococcus agalactiae / immunology*
  • Vaccination

Substances

  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Recombinant Proteins
  • SIP protein, Streptococcus group B