Araguspongines K and L, new bioactive bis-1-oxaquinolizidine N-oxide alkaloids from Red Sea specimens of Xestospongia exigua

J Nat Prod. 2002 Dec;65(12):1782-5. doi: 10.1021/np0202226.

Abstract

In addition to the previously reported (+)-araguspongine A, (+)-araguspongine C, (+)-araguspongine D, (-)-araguspongine E, and (+)-xestospongin B, two new N-oxide araguspongines, (+)-araguspongine K and (+)-araguspongine L, are described here. Their structures were established on the basis of spectral analyses including (1)H-(15)N HMBC. The promising in vitro antimalarial and antituberculosis activities of araguspongine C are reported.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Antimalarials / chemistry
  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology
  • Antitubercular Agents / chemistry
  • Antitubercular Agents / isolation & purification*
  • Antitubercular Agents / pharmacology
  • Indian Ocean
  • Molecular Structure
  • Mycobacterium tuberculosis / drug effects
  • Nuclear Magnetic Resonance, Biomolecular
  • Plasmodium falciparum / drug effects
  • Porifera / chemistry*
  • Quinolizines / chemistry
  • Quinolizines / isolation & purification*
  • Quinolizines / pharmacology
  • Rifampin / pharmacology
  • Stereoisomerism

Substances

  • Alkaloids
  • Antimalarials
  • Antitubercular Agents
  • Quinolizines
  • araguspongine C
  • araguspongine K
  • araguspongine L
  • Rifampin