Abstract
In addition to the previously reported (+)-araguspongine A, (+)-araguspongine C, (+)-araguspongine D, (-)-araguspongine E, and (+)-xestospongin B, two new N-oxide araguspongines, (+)-araguspongine K and (+)-araguspongine L, are described here. Their structures were established on the basis of spectral analyses including (1)H-(15)N HMBC. The promising in vitro antimalarial and antituberculosis activities of araguspongine C are reported.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology
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Antitubercular Agents / chemistry
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Antitubercular Agents / isolation & purification*
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Antitubercular Agents / pharmacology
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Indian Ocean
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Molecular Structure
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Mycobacterium tuberculosis / drug effects
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Nuclear Magnetic Resonance, Biomolecular
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Plasmodium falciparum / drug effects
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Porifera / chemistry*
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Quinolizines / chemistry
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Quinolizines / isolation & purification*
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Quinolizines / pharmacology
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Rifampin / pharmacology
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Stereoisomerism
Substances
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Alkaloids
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Antimalarials
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Antitubercular Agents
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Quinolizines
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araguspongine C
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araguspongine K
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araguspongine L
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Rifampin