Abstract
The present study was carried out to investigate the antioxidant effect of an ethanolic extract of Coccinia indica leaves, an indigenous plant used in Ayurvedic Medicine in India, in Streptozotocin-diabetic rats. Oral administration of Coccinia indica leaf extract (CLEt) (200 mg/kg body weight) for 45 days resulted in a significant reduction in plasma thiobarbituric acid reactive substances, hydroperoxides, vitamin E and ceruloplasmin. The extract also caused a significant increase in plasma vitamin C and reduced glutathione, which clearly shows the antioxidant property of CLEt. The effect of CLEt at 200 mg/kg body weight was more effective than glibenclamide.
Copyright 2003 John Wiley & Sons, Ltd.
MeSH terms
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Administration, Oral
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Animals
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Ascorbic Acid / blood
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Blood Glucose / drug effects
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Blood Glucose / metabolism
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Ceruloplasmin / drug effects
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Ceruloplasmin / metabolism
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Cucurbitaceae*
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Diabetes Mellitus, Experimental / chemically induced
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Diabetes Mellitus, Experimental / prevention & control*
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Glutathione / blood
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Glutathione / drug effects
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Glyburide / pharmacology
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Hypoglycemic Agents / administration & dosage
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Hypoglycemic Agents / pharmacology*
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Hypoglycemic Agents / therapeutic use
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India
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Male
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Medicine, Ayurvedic
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Leaves
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Rats
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Rats, Wistar
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Streptozocin
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Thiobarbituric Acid Reactive Substances / metabolism
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Vitamin E / blood
Substances
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Blood Glucose
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Hypoglycemic Agents
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Plant Extracts
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Thiobarbituric Acid Reactive Substances
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Vitamin E
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Streptozocin
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Ceruloplasmin
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Glutathione
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Ascorbic Acid
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Glyburide