Abstract
Otx1 belongs to the paired class of homeobox genes and plays a pivotal role in brain development. Here, we show that Otx1 is expressed in hematopoietic pluripotent and erythroid progenitor cells. Moreover, bone marrow cells from mice lacking Otx1 exhibit a cell-autonomous impairment of the erythroid compartment. In agreement with these results, molecular analysis revealed decreased levels of erythroid genes that include the SCL and GATA-1 transcription factors. Accordingly, a gain of function of SCL rescues the erythroid deficiency in Otx1-/- mice. Taken together, our findings indicate a function for Otx1 in the regulation of blood cell production.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Base Sequence
-
Basic Helix-Loop-Helix Transcription Factors
-
DNA-Binding Proteins / genetics
-
Erythropoiesis
-
Female
-
Hematopoiesis*
-
Homeodomain Proteins / genetics
-
Homeodomain Proteins / physiology*
-
Mice
-
Mice, Inbred C57BL
-
Molecular Sequence Data
-
Otx Transcription Factors
-
Proto-Oncogene Proteins / genetics
-
T-Cell Acute Lymphocytic Leukemia Protein 1
-
Transcription Factors / genetics
-
Transcription Factors / physiology*
Substances
-
Basic Helix-Loop-Helix Transcription Factors
-
DNA-Binding Proteins
-
Homeodomain Proteins
-
Otx Transcription Factors
-
Otx1 protein, mouse
-
Proto-Oncogene Proteins
-
T-Cell Acute Lymphocytic Leukemia Protein 1
-
Tal1 protein, mouse
-
Transcription Factors