Abstract
The platinum agents (cisplatin, carboplatin and oxaliplatin) are among the most useful anticancer agents available to oncologists. The drugs have the potential to produce both mild and more serious side effects. However, in general, the platinum agents can be delivered with acceptable toxicity, even when used in combination chemotherapy regimens. Furthermore, with appropriate dose modifications, the large majority of patients who may benefit from this class of cytotoxic pharmaceutical drugs will be able to complete a planned therapeutic programme.
MeSH terms
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Antineoplastic Agents / adverse effects*
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Antineoplastic Agents / therapeutic use
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Carboplatin / adverse effects*
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Carboplatin / therapeutic use
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Cisplatin / adverse effects*
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Cisplatin / therapeutic use
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Dose-Response Relationship, Drug
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Drug Hypersensitivity / etiology
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Humans
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Kidney Diseases / chemically induced
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Neurotoxicity Syndromes / etiology
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Neutropenia / chemically induced
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Organoplatinum Compounds / adverse effects*
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Organoplatinum Compounds / therapeutic use
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Oxaliplatin
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Thrombocytopenia / chemically induced
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Vomiting / chemically induced
Substances
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Antineoplastic Agents
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Organoplatinum Compounds
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Oxaliplatin
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Carboplatin
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Cisplatin