Abstract
Nine flavonoids (1-9) have been isolated from Kaempferia parviflora. Among these, 5,7,4'-trimethoxyflavone (8) and 5,7,3',4'-tetramethoxyflavone (9) exhibited antiplasmodial activity against Plasmodium falciparum, with IC50 values of 3.70 and 4.06 microg/ml, respectively. 3,5,7,4'-Tetramethoxyflavone (7) and compound 8 possessed antifungal activity against Candida albicans with respective IC50 values of 39.71 and 17.63 microg/ml, and also showed mild antimycobacterial activity with the minimum inhibitory concentrations (MIC) of 200 and 50 microg/ml, respectively. However, none of the isolated compounds demonstrated cytotoxicity against KB, BC and NCI-H187 cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / pharmacology
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Anti-Infective Agents / therapeutic use
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Antifungal Agents / administration & dosage
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Antifungal Agents / pharmacology
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Antifungal Agents / therapeutic use
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Antimalarials / administration & dosage
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Antimalarials / pharmacology
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Antimalarials / therapeutic use
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Candida albicans / drug effects*
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Flavonoids / administration & dosage
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Flavonoids / pharmacology
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Flavonoids / therapeutic use
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Inhibitory Concentration 50
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Microbial Sensitivity Tests
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Mycobacterium / drug effects
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plasmodium falciparum / drug effects*
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Zingiberaceae*
Substances
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Anti-Infective Agents
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Antifungal Agents
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Antimalarials
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Flavonoids
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Plant Extracts