Abstract
Synaptotagmin (Syt) is a membrane protein family of secretory vesicles, abundant in neural and some endocrine cells. All the members of this family contain one transmembrane region and two conserved C2 domains. Here we reported a new human Syt 10 gene isolated when screening a human fetal brain cDNA library. This cDNA clone is 3287 bp and contains an open reading frame from 299 to 1870 encoding a putative protein of 523 amino acids. It shares 94.6 and 94.8% homology to rat Syt 10 and mouse Syt 10 at protein level, respectively. RT-PCR result showed that it is expressed only in pancreas, lung and kidney.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Calcium-Binding Proteins / genetics*
-
Cloning, Molecular
-
Conserved Sequence
-
Humans
-
Kidney / metabolism
-
Lung / metabolism
-
Membrane Glycoproteins / chemistry
-
Membrane Glycoproteins / genetics*
-
Membrane Proteins / genetics*
-
Molecular Sequence Data
-
Nerve Tissue Proteins / chemistry
-
Nerve Tissue Proteins / genetics*
-
Pancreas / metabolism
-
Sequence Alignment
-
Sequence Homology, Amino Acid
-
Synaptotagmins
Substances
-
Calcium-Binding Proteins
-
Membrane Glycoproteins
-
Membrane Proteins
-
Nerve Tissue Proteins
-
SYT10 protein, human
-
Synaptotagmins