Abstract
A new jatrophane diterpene, pubescenol (1), known ent-abietane lactones, helioscopinolide A (2) and B (3), and taraxerone, 24-methylenecycloartanol, and vanillin have been isolated from Euphorbia pubescens. Diterpenes 1-3 and previously described pubescene D (4) were shown to be moderate inhibitors of the growth of MCF-7, NCI-H460, and SF-268 human tumor cell lines, whereas compounds 2 and 3 also exhibited significant antibacterial activity against Staphylococcus aureus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abietanes / chemistry
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Abietanes / isolation & purification*
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Abietanes / pharmacology
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Euphorbia / chemistry*
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Humans
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Portugal
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Staphylococcus aureus / drug effects
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Stereoisomerism
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Tumor Cells, Cultured
Substances
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Abietanes
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Anti-Bacterial Agents
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Antineoplastic Agents, Phytogenic
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Diterpenes
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helioscopinolide A
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helioscopinolide B
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pubescenol